Next Article in Journal
Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells
Next Article in Special Issue
Pomegranate and Its Components as Alternative Treatment for Prostate Cancer
Previous Article in Journal
New Milk Protein-Derived Peptides with Potential Antimicrobial Activity: An Approach Based on Bioinformatic Studies
Previous Article in Special Issue
Up-Regulated FASN Expression Promotes Transcoelomic Metastasis of Ovarian Cancer Cell through Epithelial-Mesenchymal Transition
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(8), 14546-14554;

Salmonella as an Innovative Therapeutic Antitumor Agent

Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung 402, Taiwan
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Department of Microbiology, School of Medicine, China Medical University, Taichung 404, Taiwan
Author to whom correspondence should be addressed.
Received: 24 June 2014 / Revised: 28 July 2014 / Accepted: 18 August 2014 / Published: 21 August 2014
(This article belongs to the Special Issue Advances in Molecular Oncology 2014)
Full-Text   |   PDF [943 KB, uploaded 22 August 2014]   |  


Lack of specificity of the therapeutic agent is a primary limitation in the treatment of a tumor. The use of preferentially replicating bacteria as therapeutic agents is an innovative approach to tumor treatment. This is based on the observation that certain obligate or facultative anaerobic bacteria are capable of multiplying selectively in tumors and inhibiting their growth. Bacteria have been employed as antitumor agents that are capable of preferentially amplifying within tumors and inhibiting their growth. Moreover, bacteria-derived factors have an immune-stimulation effect. Therefore, bacteria are able to transfer therapeutic genes into the tumor cells using their infective ability. Herein, we introduce the application of bacteria for tumor therapy and focus on Salmonella, which have been widely used for tumor therapy. Salmonella have mainly been applied as gene-delivery vectors, antitumor immune activators and tumor cell death inducers. This study will not only evaluate the therapeutic efficacy of Salmonella for the treatment of tumor but will also elucidate the mechanisms underlying the antitumor activities mediated by Salmonella, which involve host immune responses and cellular molecular responses. View Full-Text
Keywords: Salmonella; tumor-targeting; antitumor; immunotherapy Salmonella; tumor-targeting; antitumor; immunotherapy

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Chang, W.-W.; Lee, C.-H. Salmonella as an Innovative Therapeutic Antitumor Agent. Int. J. Mol. Sci. 2014, 15, 14546-14554.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top