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Iodine Excess as an Environmental Risk Factor for Autoimmune Thyroid Disease

1
Laboratory of Molecular Diagnostics, Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Disease, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan
2
Department of Education Planning and Development, Faculty of Medicine, Toho University, Tokyo 143-8540, Japan
3
Department of Medicine and Bioregulatory Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
4
Leprosy Research Center, National Institute of Infectious Disease, 4-2-1 Aoba-cho, Higashimurayama-shi, Tokyo 189-0002, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(7), 12895-12912; https://doi.org/10.3390/ijms150712895
Received: 19 June 2014 / Revised: 3 July 2014 / Accepted: 15 July 2014 / Published: 21 July 2014
(This article belongs to the Special Issue Environmental Toxicants and Autoimmune Disease)
The global effort to prevent iodine deficiency disorders through iodine supplementation, such as universal salt iodization, has achieved impressive progress during the last few decades. However, iodine excess, due to extensive environmental iodine exposure in addition to poor monitoring, is currently a more frequent occurrence than iodine deficiency. Iodine excess is a precipitating environmental factor in the development of autoimmune thyroid disease. Excessive amounts of iodide have been linked to the development of autoimmune thyroiditis in humans and animals, while intrathyroidal depletion of iodine prevents disease in animal strains susceptible to severe thyroiditis. Although the mechanisms by which iodide induces thyroiditis are still unclear, several mechanisms have been proposed: (1) excess iodine induces the production of cytokines and chemokines that can recruit immunocompetent cells to the thyroid; (2) processing excess iodine in thyroid epithelial cells may result in elevated levels of oxidative stress, leading to harmful lipid oxidation and thyroid tissue injuries; and (3) iodine incorporation in the protein chain of thyroglobulin may augment the antigenicity of this molecule. This review will summarize the current knowledge regarding excess iodide as an environmental toxicant and relate it to the development of autoimmune thyroid disease. View Full-Text
Keywords: excess iodine; autoimmune thyroid disease; environmental toxicant; immune response; tissue injury; thyroglobulin excess iodine; autoimmune thyroid disease; environmental toxicant; immune response; tissue injury; thyroglobulin
MDPI and ACS Style

Luo, Y.; Kawashima, A.; Ishido, Y.; Yoshihara, A.; Oda, K.; Hiroi, N.; Ito, T.; Ishii, N.; Suzuki, K. Iodine Excess as an Environmental Risk Factor for Autoimmune Thyroid Disease. Int. J. Mol. Sci. 2014, 15, 12895-12912.

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