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Int. J. Mol. Sci. 2014, 15(7), 11973-11983; https://doi.org/10.3390/ijms150711973

miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

1
Department of Thoracic-Cardio Surgery, the First Affiliated Hospital of PLA General Hospital, Beijing 100048, China
2
Department of Medical Oncology, the General Hospital of People's Liberation Army, Beijing 100853, China
3
Department of Thoracic Surgery, the General Hospital of People's Liberation Army, Beijing 100853, China
4
Key Laboratory of Cancer Prevention and Therapy of Tianjin, Department of Senior Ward, Tianjin Medical University Cancer Institute and Hospital, Huanhu Xilu, Hexi District, Tianjin 300060, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 7 May 2014 / Revised: 9 June 2014 / Accepted: 16 June 2014 / Published: 7 July 2014
(This article belongs to the Section Biochemistry)
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PDF [740 KB, uploaded 7 July 2014]
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Abstract

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC. View Full-Text
Keywords: miR-143; NSCLC; Limk1; proliferation; migration; invasion miR-143; NSCLC; Limk1; proliferation; migration; invasion
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Xia, H.; Sun, S.; Wang, B.; Wang, T.; Liang, C.; Li, G.; Huang, C.; Qi, D.; Chu, X. miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1. Int. J. Mol. Sci. 2014, 15, 11973-11983.

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