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Int. J. Mol. Sci. 2014, 15(7), 11730-11741;

Biodegradable and Multifunctional Polymer Micro-Tubes for Targeting Photothermal Therapy

Food Science College, Northeast Agricultural University, 59 GongBin Road, XiangFang District, Harbin 150030, China
School of Clinical Medical, Heilongjiang University of Chinese Medicine, Harbin 150040, China
Heilongjiang International Travel Healthcare Center, 9 GanShui Road, Harbin 150036, China
School of Food Science and Engineering, Harbin Institute of Technology, 73 HuangHe Road, NanGang District, Harbin 150090, China
Author to whom correspondence should be addressed.
Received: 2 May 2014 / Revised: 30 May 2014 / Accepted: 24 June 2014 / Published: 2 July 2014
(This article belongs to the Section Materials Science)
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We describe an innovative form of polymer micro-tubes with diverse functions including biodegradation, magnetic manipulation, and photothermal effect that employs and activates photothermal therapy to target cancer cells. The micro-tube comprised soybean protein isolate, poly-l-glutamic acid, magnetite nanoparticles, plus gold nanoparticles. Through electrostatic force, these components, with opposite charges, formed pairs of layers in the pores of the template, various bilayers of soybean protein isolate and poly-l-glutamic acid served as the biodegradable building wall to each micro-tube. The layers of magnetite nanoparticle functionalized micro-tubes enabled the micro-tube manipulate to target the cancer cells by using an external magnetic field. The photo-thermal effect of the layer of gold nanoparticles on the outer surface of the micro-tubes, when under irradiation and when brought about by the near infrared radiation, elevated each sample’s temperature. In addition, and when under the exposure of the near infrared radiation, the elevated temperature of the suspension of the micro-tubes, likewise with a concentration of 0.2 mg/mL, and similarly with a power of 2 W and as well maintained for 10 min, elevated the temperature of the suspension beyond 42 °C. Such temperatures induced apoptosis of target cancer cells through the effect of photothermal therapy. The findings assert that structured micro-tubes have a promising application as a photothermal agent. From this assertion, the implications are that this multifunctional agent will significantly improve the methodology for cancer diagnosis and therapy. View Full-Text
Keywords: micro-tube; soybean protein isolate; magnetic manipulation; photothermal therapy micro-tube; soybean protein isolate; magnetic manipulation; photothermal therapy

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Wang, X.; Yu, G.; Han, X.; Zhang, H.; Ren, J.; Wu, X.; Qu, Y. Biodegradable and Multifunctional Polymer Micro-Tubes for Targeting Photothermal Therapy. Int. J. Mol. Sci. 2014, 15, 11730-11741.

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