Next Article in Journal
Multiplex Hydrolysis Probe Real-Time PCR for Simultaneous Detection of Hepatitis A Virus and Hepatitis E Virus
Previous Article in Journal
Gamma Knife Treatment of Brainstem Metastases
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(6), 9762-9779;

Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury

Department of Respiratory and Critical Medicine, the People's Hospital of Zhengzhou University, Zhengzhou 450003, China
Department of Gastroenterology, the People's Hospital of Zhengzhou University, Zhengzhou 450003, China
Department of Infectious Disease, Anhui Provincial Hospital, Hefei 230001, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 18 February 2013 / Revised: 16 March 2014 / Accepted: 22 May 2014 / Published: 30 May 2014
Full-Text   |   PDF [3524 KB, uploaded 19 June 2014]   |  


Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin is a tannin derivative which shows anti-inflammatory and antifibrotics properties and is potentiated in treating IPF. Here, we investigated the effect of corilagin on lung injury following bleomycin exposure in an animal model of pulmonary fibrosis. Corilagin abrogated bleomycin-induced lung fibrosis as assessed by H&E; Masson’s trichrome staining and lung hydroxyproline content in lung tissue. Corilagin reduced the number of apoptotic lung cells and prevented lung epithelial cells from membrane breakdown, effluence of lamellar bodies and thickening of the respiratory membrane. Bleomycin exposure induced expression of MDA, IKKα, phosphorylated IKKα (p-IKKα), NF-κB P65, TNF-α and IL-1β, and reduced I-κB expression in mice lung tissue or in BALF. These changes were reversed by high-dose corilagin (100 mg/kg i.p) more dramatically than by low dose (10 mg/kg i.p). Last, corilagin inhibits TGF-β1 production and α-SMA expression in lung tissue samples. Taken together, these findings confirmed that corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling. Corilagin may serve as a promising therapeutic agent for pulmonary fibrosis. View Full-Text
Keywords: pulmonary fibrosis; corilagin; NF-κB; apoptosis; TGF-β1 pulmonary fibrosis; corilagin; NF-κB; apoptosis; TGF-β1

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Wang, Z.; Guo, Q.-Y.; Zhang, X.-J.; Li, X.; Li, W.-T.; Ma, X.-T.; Ma, L.-J. Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury. Int. J. Mol. Sci. 2014, 15, 9762-9779.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top