Next Article in Journal
Metabolic Profiling of Somatic Tissues from Monochamus alternatus (Coleoptera: Cerambycidae) Reveals Effects of Irradiation on Metabolism
Previous Article in Journal
An Efficient Agrobacterium-Mediated Transformation System for Poplar
Open AccessArticle

High-Salt Intake Suppressed MicroRNA-133a Expression in Dahl SS Rat Myocardium

Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an 710061, China
Department of Cardiovascular Medicine, Xi'an No. 4 Hospital, No. 21 Jiefang Road, Xi'an 710004, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(6), 10794-10805;
Received: 3 May 2014 / Revised: 6 June 2014 / Accepted: 9 June 2014 / Published: 16 June 2014
(This article belongs to the Section Physical Chemistry, Theoretical and Computational Chemistry)
Salt-sensitive individuals show earlier and more serious cardiac damage than nonsalt-sensitive ones. Some studies have suggested that microRNA-133a could reduce cardiac hypertrophy and myocardial fibrosis. The current study aims to investigate the different functions of high-salt intake on salt-sensitive (SS) rats and Sprague-Dawley (SD) rats and the involvement of microRNA-133a in these roles. After high-salt intervention, the left ventricular mass (LVW) and left ventricular mass index (LVMI) of the salt-sensitive high salt (SHS) group were obviously higher than those of the salt-sensitive low salt (SLS) group. However, the difference between the Sprague-Dawley high salt (DHS) group and the Sprague-Dawley low salt (DLS) group was not significant. Compared with SLS group, collagen I and connective tissue growth factor (CTGF) in the heart of SHS group were significantly higher, whereas no statistical difference was observed between the DHS group and the DLS group. Compared with low-salt diet, microRNA-133a in the heart of both strains were significantly decreased, but that in the SHS group decreased more significantly. These results suggest that high salt intervention could down-regulate the expression of myocardial microRNA-133a, which may be one of the mechanisms involved in myocardial fibrosis in salt-sensitive hypertension. View Full-Text
Keywords: salt-sensitivity; myocardial fibrosis; microRNA-133a salt-sensitivity; myocardial fibrosis; microRNA-133a
Show Figures

Graphical abstract

MDPI and ACS Style

Guo, T.-S.; Zhang, J.; Mu, J.-J.; Liu, F.-Q.; Yuan, Z.-Y.; Ren, K.-Y.; Wang, D. High-Salt Intake Suppressed MicroRNA-133a Expression in Dahl SS Rat Myocardium. Int. J. Mol. Sci. 2014, 15, 10794-10805.

Show more citation formats Show less citations formats

Article Access Map

Only visits after 24 November 2015 are recorded.
Back to TopTop