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Open AccessReview

BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants

1
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China
2
Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands
3
Department of Oral Implantology and Prosthetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University Amsterdam and University of Amsterdam, Amsterdam 1081LA, The Netherlands
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(6), 10150-10168; https://doi.org/10.3390/ijms150610150
Received: 17 April 2014 / Revised: 13 May 2014 / Accepted: 22 May 2014 / Published: 6 June 2014
(This article belongs to the Special Issue Biologic Coatings for Orthopaedic Implant)
The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants. View Full-Text
Keywords: bone morphogenetic protein; coating; orthopaedic implant; osteogenesis bone morphogenetic protein; coating; orthopaedic implant; osteogenesis
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Wang, J.; Guo, J.; Liu, J.; Wei, L.; Wu, G. BMP-Functionalised Coatings to Promote Osteogenesis for Orthopaedic Implants. Int. J. Mol. Sci. 2014, 15, 10150-10168.

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