Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction

Cabigas, E. Bernadette; Somasuntharam, Inthirai; Brown, Milton E.; Che, Pao Lin; Pendergrass, Karl D.; Chiang, Bryce; Taylor, W. Robert; Davis, Michael E.

doi:10.3390/ijms15059036

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Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction

E. Bernadette Cabigas

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Inthirai Somasuntharam

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Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA

Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA

Emory Children's Center for Cardiovascular Biology, Children's Healthcare of Atlanta, Atlanta, GA 30322, USA

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2014, 15(5), 9036-9050; https://doi.org/10.3390/ijms15059036

Received: 17 April 2014 / Revised: 12 May 2014 / Accepted: 14 May 2014 / Published: 21 May 2014

(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)

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Abstract

Cardiovascular disease is the leading cause of death in the United States and new treatment options are greatly needed. Oxidative stress is increased following myocardial infarction and levels of antioxidants decrease, causing imbalance that leads to dysfunction. Therapy involving catalase, the endogenous scavenger of hydrogen peroxide (H₂O₂), has been met with mixed results. When over-expressed in cardiomyocytes from birth, catalase improves function following injury. When expressed in the same cells in an inducible manner, catalase showed a time-dependent response with no acute benefit, but a chronic benefit due to altered remodeling. In myeloid cells, catalase over-expression reduced angiogenesis during hindlimb ischemia and prevented monocyte migration. In the present study, due to the large inflammatory response following infarction, we examined myeloid-specific catalase over-expression on post-infarct healing. We found a significant increase in catalase levels following infarction that led to a decrease in H₂O₂ levels, leading to improved acute function. This increase in function could be attributed to reduced infarct size and improved angiogenesis. Despite these initial improvements, there was no improvement in chronic function, likely due to increased fibrosis. These data combined with what has been previously shown underscore the need for temporal, cell-specific catalase delivery as a potential therapeutic option. View Full-Text

Keywords: oxidative stress; myocardial infarction; antioxidant therapy

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Cabigas, E.B.; Somasuntharam, I.; Brown, M.E.; Che, P.L.; Pendergrass, K.D.; Chiang, B.; Taylor, W.R.; Davis, M.E. Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction. Int. J. Mol. Sci. 2014, 15, 9036-9050. https://doi.org/10.3390/ijms15059036

AMA Style

Cabigas EB, Somasuntharam I, Brown ME, Che PL, Pendergrass KD, Chiang B, Taylor WR, Davis ME. Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction. International Journal of Molecular Sciences. 2014; 15(5):9036-9050. https://doi.org/10.3390/ijms15059036

Chicago/Turabian Style

Cabigas, E. B., Inthirai Somasuntharam, Milton E. Brown, Pao L. Che, Karl D. Pendergrass, Bryce Chiang, W. R. Taylor, and Michael E. Davis. 2014. "Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction" International Journal of Molecular Sciences 15, no. 5: 9036-9050. https://doi.org/10.3390/ijms15059036

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Over-Expression of Catalase in Myeloid Cells Confers Acute Protection Following Myocardial Infarction

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