Next Article in Journal
Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-κB Pathway
Next Article in Special Issue
Expression and Effects of High-Mobility Group Box 1 in Cervical Cancer
Previous Article in Journal
The Effect and Mechanism of Tamoxifen-Induced Hepatocyte Steatosis in Vitro
Previous Article in Special Issue
Casein Kinase 1 Epsilon Expression Predicts Poorer Prognosis in Low T-Stage Oral Cancer Patients
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2014, 15(3), 4031-4048;

Role of miR-191/425 Cluster in Tumorigenesis and Diagnosis of Gastric Cancer

Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
Authors to whom correspondence should be addressed.
Received: 17 January 2014 / Revised: 18 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014
Full-Text   |   PDF [1838 KB, uploaded 19 June 2014]


Gastric cancer (GC) is among the most frequent types of cancer worldwide. Therefore, understanding the biology of GC tumorigenesis is important for appropriate diagnosis and patient surveillance. The miR-191/425 cluster has been reported to be overexpressed in various human cancers, but the tumorigenic role and clinical significance of miR-191/425 overexpression in gastric carcinogenesis is currently undefined. In this study, the expression of miR-191 and miR-425 in GC tissue and serum was assessed, and the relationship between miRNA expression and clinicopathological data was analyzed. We found that miR-191 and miR-425 were both significantly increased in human GC tissues relative to adjacent normal controls. In addition, miR-191 levels correlated with GC tumor stage and metastatic state. Furthermore, the level of serum miR-191 was significantly higher in the GC group than in the control group when using serum miR-16 as an endogenous control. Finally, inhibition of miR-191 or miR-425 in the GC cell lines HGC-27 not only reduced cell proliferation and cell cycle progression but also impaired cell migration and invasion. Taken together, our results revealed the oncogenic roles of miR-191 and miR-425 in gastric carcinogenesis, and indicated the potential use of serum miR-191 as a novel and stable biomarker for GC diagnosis. View Full-Text
Keywords: miR-191; miR-425; serum miRNA; gastric cancer miR-191; miR-425; serum miRNA; gastric cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Peng, W.-Z.; Ma, R.; Wang, F.; Yu, J.; Liu, Z.-B. Role of miR-191/425 Cluster in Tumorigenesis and Diagnosis of Gastric Cancer. Int. J. Mol. Sci. 2014, 15, 4031-4048.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top