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Int. J. Mol. Sci. 2014, 15(3), 4031-4048; https://doi.org/10.3390/ijms15034031

Role of miR-191/425 Cluster in Tumorigenesis and Diagnosis of Gastric Cancer

1
Department of General Surgery, China-Japan Friendship Hospital, Beijing 100029, China
2
Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
*
Authors to whom correspondence should be addressed.
Received: 17 January 2014 / Revised: 18 February 2014 / Accepted: 19 February 2014 / Published: 5 March 2014
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Abstract

Gastric cancer (GC) is among the most frequent types of cancer worldwide. Therefore, understanding the biology of GC tumorigenesis is important for appropriate diagnosis and patient surveillance. The miR-191/425 cluster has been reported to be overexpressed in various human cancers, but the tumorigenic role and clinical significance of miR-191/425 overexpression in gastric carcinogenesis is currently undefined. In this study, the expression of miR-191 and miR-425 in GC tissue and serum was assessed, and the relationship between miRNA expression and clinicopathological data was analyzed. We found that miR-191 and miR-425 were both significantly increased in human GC tissues relative to adjacent normal controls. In addition, miR-191 levels correlated with GC tumor stage and metastatic state. Furthermore, the level of serum miR-191 was significantly higher in the GC group than in the control group when using serum miR-16 as an endogenous control. Finally, inhibition of miR-191 or miR-425 in the GC cell lines HGC-27 not only reduced cell proliferation and cell cycle progression but also impaired cell migration and invasion. Taken together, our results revealed the oncogenic roles of miR-191 and miR-425 in gastric carcinogenesis, and indicated the potential use of serum miR-191 as a novel and stable biomarker for GC diagnosis. View Full-Text
Keywords: miR-191; miR-425; serum miRNA; gastric cancer miR-191; miR-425; serum miRNA; gastric cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Peng, W.-Z.; Ma, R.; Wang, F.; Yu, J.; Liu, Z.-B. Role of miR-191/425 Cluster in Tumorigenesis and Diagnosis of Gastric Cancer. Int. J. Mol. Sci. 2014, 15, 4031-4048.

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