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The Role of Reactive Oxygen Species in Microvascular Remodeling

Dalton Cardiovascular Research Center, and Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
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Int. J. Mol. Sci. 2014, 15(12), 23792-23835; https://doi.org/10.3390/ijms151223792
Received: 30 October 2014 / Revised: 5 December 2014 / Accepted: 10 December 2014 / Published: 19 December 2014
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
The microcirculation is a portion of the vascular circulatory system that consists of resistance arteries, arterioles, capillaries and venules. It is the place where gases and nutrients are exchanged between blood and tissues. In addition the microcirculation is the major contributor to blood flow resistance and consequently to regulation of blood pressure. Therefore, structural remodeling of this section of the vascular tree has profound implications on cardiovascular pathophysiology. This review is focused on the role that reactive oxygen species (ROS) play on changing the structural characteristics of vessels within the microcirculation. Particular attention is given to the resistance arteries and the functional pathways that are affected by ROS in these vessels and subsequently induce vascular remodeling. The primary sources of ROS in the microcirculation are identified and the effects of ROS on other microcirculatory remodeling phenomena such as rarefaction and collateralization are briefly reviewed. View Full-Text
Keywords: resistance arteries; microcirculation; inward remodeling; NADPH oxidase; Nox; xanthine oxidase; mitochondria; superoxide; hypertension resistance arteries; microcirculation; inward remodeling; NADPH oxidase; Nox; xanthine oxidase; mitochondria; superoxide; hypertension
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Staiculescu, M.C.; Foote, C.; Meininger, G.A.; Martinez-Lemus, L.A. The Role of Reactive Oxygen Species in Microvascular Remodeling. Int. J. Mol. Sci. 2014, 15, 23792-23835.

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