Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone
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Feng-Lai Yuan 1,2, Ming-Dong Zhao 1, Li-Bo Jiang 1, Hui-Ren Wang 1, Lu Cao 1, Xiao-Gang Zhou 1, Xi-Lei Li 1 and Jian Dong 1,*
Feng-Lai Yuan 1,2, Ming-Dong Zhao 1, Li-Bo Jiang 1, Hui-Ren Wang 1, Lu Cao 1, Xiao-Gang Zhou 1, Xi-Lei Li 1 and Jian Dong 1,*
1
Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2
Department of Orthopaedics and Central Laboratory, the Third Hospital Affiliated of Nantong University, Wuxi 214041, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(12), 22365-22373; https://doi.org/10.3390/ijms151222365
Received: 28 September 2014 / Revised: 13 November 2014 / Accepted: 17 November 2014 / Published: 3 December 2014
(This article belongs to the Collection G Protein-Coupled Receptor Signaling and Regulation)
Extracellular acidification occurs under physiologic and pathologic conditions, such as exercise, ischemia, and inflammation. It has been shown that acidosis has various adverse effects on bone. In recent years there has been increasing evidence which indicates that ovarian cancer G protein-coupled receptor 1 (OGR1) is a pH-sensing receptor and mediates a variety of extracellular acidification-induced actions on bone cells and other cell types. Recent studies have shown that OGR1 is involved in the regulation of osteoclast differentiation, survival, and function, as well as osteoblast differentiation and bone formation. Moreover, OGR1 also regulates acid-induced apoptosis of endplate chondrocytes in intervertebral discs. These observations demonstrate the importance of OGR1 in skeletal development and metabolism. Here, we provide an overview of OGR1 regulation ofosteoclasts, osteoblasts, and chondrocytes, and the molecular actions of OGR1 induced by extracellular acidification in the maintenance of bone health.
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MDPI and ACS Style
Yuan, F.-L.; Zhao, M.-D.; Jiang, L.-B.; Wang, H.-R.; Cao, L.; Zhou, X.-G.; Li, X.-L.; Dong, J. Molecular Actions of Ovarian Cancer G Protein-Coupled Receptor 1 Caused by Extracellular Acidification in Bone. Int. J. Mol. Sci. 2014, 15, 22365-22373.
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