Post-Transcriptional Up-Regulation of PDGF-C by HuR in Advanced and Stressed Breast Cancer
AbstractBreast cancer is a heterogeneous disease characterized by multiple genetic alterations leading to the activation of growth factor signaling pathways that promote cell proliferation. Platelet-derived growth factor-C (PDGF-C) is overexpressed in various malignancies; however, the involvement of PDGF-C in breast cancers and the mechanisms underlying PDGF-C deregulation remain unclear. Here, we show that PDGF-C is overexpressed in clinical breast cancers and correlates with poor prognosis. PDGF-C up-regulation was mediated by the human embryonic lethal abnormal vision-like protein HuR, which stabilizes the PDGF-C transcript by binding to two predicted AU-rich elements (AREs) in the 3'-untranslated region (3'-UTR). HuR is up-regulated in hydrogen peroxide-treated or ultraviolet-irradiated breast cancer cells. Clinically, HuR levels are correlated with PDGF-C expression and histological grade or pathological tumor-node-metastasis (pTNM) stage. Our findings reveal a novel mechanism underlying HuR-mediated breast cancer progression, and suggest that HuR and PDGF-C are potential molecular candidates for targeted therapy of breast cancers. View Full-Text
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Luo, N.-A.; Qu, Y.-Q.; Yang, G.-D.; Wang, T.; Li, R.-L.; Jia, L.-T.; Dong, R. Post-Transcriptional Up-Regulation of PDGF-C by HuR in Advanced and Stressed Breast Cancer. Int. J. Mol. Sci. 2014, 15, 20306-20320.
Luo N-A, Qu Y-Q, Yang G-D, Wang T, Li R-L, Jia L-T, Dong R. Post-Transcriptional Up-Regulation of PDGF-C by HuR in Advanced and Stressed Breast Cancer. International Journal of Molecular Sciences. 2014; 15(11):20306-20320.Chicago/Turabian Style
Luo, Nian-An; Qu, Ya-Qi; Yang, Guo-Dong; Wang, Tao; Li, Ren-Li; Jia, Lin-Tao; Dong, Rui. 2014. "Post-Transcriptional Up-Regulation of PDGF-C by HuR in Advanced and Stressed Breast Cancer." Int. J. Mol. Sci. 15, no. 11: 20306-20320.