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Int. J. Mol. Sci. 2014, 15(11), 19791-19815;

Hypoxic Signaling During Tissue Repair and Regenerative Medicine

Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
Skin Nederland BV, De Boelelaan 1117, Amsterdam 1007 MB, The Netherlands
Author to whom correspondence should be addressed.
Received: 6 August 2014 / Revised: 12 September 2014 / Accepted: 15 October 2014 / Published: 31 October 2014
(This article belongs to the Special Issue Signal Transduction of Tissue Repair)
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In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies. View Full-Text
Keywords: angiogenesis; HIF-1α; HIF-2α; hypoxia; tissue engineering; wound healing angiogenesis; HIF-1α; HIF-2α; hypoxia; tissue engineering; wound healing

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Nauta, T.D.; van Hinsbergh, V.W.M.; Koolwijk, P. Hypoxic Signaling During Tissue Repair and Regenerative Medicine. Int. J. Mol. Sci. 2014, 15, 19791-19815.

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