Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental Section
4. Conclusions
Supplementary Information
ijms-14-08381-s001.pdfAcknowledgments
Conflict of Interest
References
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Cases, n = 398 | Controls, n = 421 | p value | |
---|---|---|---|
Mean Age (sd) | 61.9 (10.7) | 61.4 (7.4) | 0.20 |
Sex, n (%) | |||
Male | 236 (59) | 246 (58) | 0.80 |
Female | 162 (41) | 175 (42) | |
Smoking Status, n (%) | |||
Current | 206 (52) | 196 (47) | 0.14 |
Former | 192 (48) | 225 (53) | |
FTND nicotine dependence score (sd) a | 4.81 (2.28) | 4.81 (2.56) | 0.96 |
No. cigarettes per day (sd) | 27.4 (13.2) | 26.8 (14.6) | 0.27 |
Years smoked (sd) | 36.9 (12.3) | 35.6 (11.8) | 0.22 |
CYP2B6*6 genotyping, n (%) | |||
*1/*1 | 221 (56) | 240 (57) | 0.71 |
*1/*6 | 157 (39) | 156 (37) | |
*6/*6 | 20 (5) | 25 (6) | |
CYP2A6 genotype groups b, n (%) | |||
CYP2A6 NM (normal metabolizer) | 326 (82) | 327 (78) | 0.13 |
CYP2A6 RM (reduced metabolizer) | 72 (18) | 94 (22) | |
CHRNA5-A3-B4 genotype groups c, n (%) | |||
A5-A3-B4 GG or GA | 330 (83) | 372 (88) | 0.03 |
A5-A3-B4 AA | 68 (17) | 49 (12) |
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Wassenaar, C.A.; Dong, Q.; Amos, C.I.; Spitz, M.R.; Tyndale, R.F. Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. Int. J. Mol. Sci. 2013, 14, 8381-8392. https://doi.org/10.3390/ijms14048381
Wassenaar CA, Dong Q, Amos CI, Spitz MR, Tyndale RF. Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis. International Journal of Molecular Sciences. 2013; 14(4):8381-8392. https://doi.org/10.3390/ijms14048381
Chicago/Turabian StyleWassenaar, Catherine A., Qiong Dong, Christopher I. Amos, Margaret R. Spitz, and Rachel F. Tyndale. 2013. "Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis" International Journal of Molecular Sciences 14, no. 4: 8381-8392. https://doi.org/10.3390/ijms14048381