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Open AccessArticle

Synthesis of 1-isopropyl-3-acyl-5-methyl-benzimidazolone Derivatives and Their Antimicrobial Activity

College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China
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Int. J. Mol. Sci. 2013, 14(4), 6790-6804; https://doi.org/10.3390/ijms14046790
Received: 22 January 2013 / Revised: 6 March 2013 / Accepted: 8 March 2013 / Published: 26 March 2013
(This article belongs to the Section Biochemistry)
A series of N-acylated analogues of 1-isopropyl-3-acyl-5-methyl-benzimidazolone were synthesized. Bioassay results indicated that analogues 5-07 and 5-19 exhibited the most potency against Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Analogues 5-02, 5-07, 5-12, 5-15, 5-19, 5-20 and 5-25 could effectively inhibit the spore germination of Botrytis cinerea. The relationship between structure and their antimicrobial activity (SAR) has also been discussed according to aliphatic acids and aromatic acids derivatives, respectively. This implied that the N-acylated derivatives of 5-methyl-benzimidazolone might be potential antimicrobial agents. View Full-Text
Keywords: 5-methyl-benzimidazolone; N-acylated derivatives; antimicrobial activity 5-methyl-benzimidazolone; N-acylated derivatives; antimicrobial activity
MDPI and ACS Style

Xu, N.; Yang, C.; Gan, X.; Wei, S.; Ji, Z. Synthesis of 1-isopropyl-3-acyl-5-methyl-benzimidazolone Derivatives and Their Antimicrobial Activity. Int. J. Mol. Sci. 2013, 14, 6790-6804.

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