Next Article in Journal
Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Next Article in Special Issue
Biological Functional Relevance of Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease
Previous Article in Journal
New Potential Antitumor Pyrazole Derivatives: Synthesis and Cytotoxic Evaluation
Previous Article in Special Issue
Determination of Homoarginine, Arginine, NMMA, ADMA, and SDMA in Biological Samples by HPLC-ESI-Mass Spectrometry
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2013, 14(11), 21819-21832;

Opposite Associations of Plasma Homoarginine and Ornithine with Arginine in Healthy Children and Adolescents

Almed-Elektra Medical Center, 41-710 Ruda Śląska, Poland
Institute for Clinical Pharmacology, Otto-von-Guericke University, 39120 Magdeburg, Germany
Department of Coronary Artery Disease, the John Paul II Hospital, 31-202 Cracow, Poland
Department of Cardiology, Congenital Heart Defects and Electrotherapy, Silesian Center for Heart Diseases in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland
Department of Cardiology, Jagiellonian University Medical College and University Hospital, 31-501 Cracow, Poland
Author to whom correspondence should be addressed.
Received: 12 August 2013 / Revised: 20 September 2013 / Accepted: 9 October 2013 / Published: 4 November 2013
(This article belongs to the Special Issue ADMA and Nitrergic System)
Full-Text   |   PDF [227 KB, uploaded 19 June 2014]


Homoarginine, a non-proteinogenic amino acid, is formed when lysine replaces ornithine in reactions catalyzed by hepatic urea cycle enzymes or lysine substitutes for glycine as a substrate of renal arginine:glycine amidinotransferase. Decreased circulating homoarginine and elevated ornithine, a downstream product of arginase, predict adverse cardiovascular outcome. Our aim was to investigate correlates of plasma homoarginine and ornithine and their relations with carotid vascular structure in 40 healthy children and adolescents aged 3–18 years without coexistent diseases or subclinical carotid atherosclerosis. Homoarginine, ornithine, arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) were measured by liquid chromatography-tandem mass spectrometry with stable isotope-labeled internal standards. Intima-media thickness (IMT) and extra-medial thickness (EMT) of common carotid arteries were estimated by B-mode ultrasound. Homoarginine correlated with arginine (r = 0.43, p = 0.005), age (r = 0.42, p = 0.007) and, weakly, with an increased arginine-to-ornithine ratio, a putative measure of lower arginase activity (r = 0.31, p = 0.048). Ornithine correlated inversely with arginine (r = −0.64, p < 0.001). IMT, EMT or their sum were unrelated to any of the biochemical parameters (p > 0.12). Thus, opposite associations of plasma homoarginine and ornithine with arginine may partially result from possible involvement of arginase, an enzyme controlling homoarginine degradation and ornithine synthesis from arginine. Age-dependency of homoarginine levels can reflect developmental changes in homoarginine metabolism. However, neither homoarginine nor ornithine appears to be associated with carotid vascular structure in healthy children and adolescents. View Full-Text
Keywords: homoarginine; ornithine; arginine; children; carotid vascular structure homoarginine; ornithine; arginine; children; carotid vascular structure
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Jaźwińska-Kozuba, A.; Martens-Lobenhoffer, J.; Kruszelnicka, O.; Rycaj, J.; Chyrchel, B.; Surdacki, A.; Bode-Böger, S.M. Opposite Associations of Plasma Homoarginine and Ornithine with Arginine in Healthy Children and Adolescents. Int. J. Mol. Sci. 2013, 14, 21819-21832.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top