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Spatial Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis

Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA
Int. J. Mol. Sci. 2013, 14(1), 72-87;
Received: 20 November 2012 / Revised: 10 December 2012 / Accepted: 12 December 2012 / Published: 20 December 2012
(This article belongs to the Special Issue Signalling Molecules and Signal Transduction in Cells)
PDF [156 KB, uploaded 19 June 2014]


Signaling by cell surface receptors appears to be relatively straight-forward: ligand binds to the extracellular domain of the receptor and biochemical changes are communicated into the cell. However, this process is more complex than it first seems due to the various mechanisms that regulate signaling. In order to effectively target these receptors for pharmacological purposes, a more complete understanding of how their signaling is regulated is needed. Here, how the endocytic pathway regulates receptor signaling is discussed, using the epidermal growth factor receptor (EGFR) as a model. In particular, the spatial regulation of signaling is examined. Areas of discussion include: how endocytic trafficking affects biology/pathology, varying approaches for studying the relationship between receptor endocytosis and signaling, and developments in how the endocytic pathway controls EGFR:effector communication and EGFR-mediated cell biology. View Full-Text
Keywords: epidermal growth factor receptor; endocytosis; signal transduction epidermal growth factor receptor; endocytosis; signal transduction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Ceresa, B.P. Spatial Regulation of Epidermal Growth Factor Receptor Signaling by Endocytosis. Int. J. Mol. Sci. 2013, 14, 72-87.

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