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Structural DNA Nanotechnology: From Design to Applications

1
Center for DNA Nanotechnology (CDNA), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark
2
Department of Chemistry, Marshall University, Huntington, WV 25755, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(6), 7149-7162; https://doi.org/10.3390/ijms13067149
Received: 2 May 2012 / Revised: 29 May 2012 / Accepted: 4 June 2012 / Published: 11 June 2012
(This article belongs to the Special Issue Self-Assembled Soft Matter Nanostructures at Interfaces)
The exploitation of DNA for the production of nanoscale architectures presents a young yet paradigm breaking approach, which addresses many of the barriers to the self-assembly of small molecules into highly-ordered nanostructures via construct addressability. There are two major methods to construct DNA nanostructures, and in the current review we will discuss the principles and some examples of applications of both the tile-based and DNA origami methods. The tile-based approach is an older method that provides a good tool to construct small and simple structures, usually with multiply repeated domains. In contrast, the origami method, at this time, would appear to be more appropriate for the construction of bigger, more sophisticated and exactly defined structures. View Full-Text
Keywords: DNA nanotechnology; self-assembly; nanostructures; DNA origami DNA nanotechnology; self-assembly; nanostructures; DNA origami
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Zadegan, R.M.; Norton, M.L. Structural DNA Nanotechnology: From Design to Applications. Int. J. Mol. Sci. 2012, 13, 7149-7162.

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