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Open AccessArticle

Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

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College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China
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Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2012, 13(4), 4696-4703; https://doi.org/10.3390/ijms13044696
Received: 20 February 2012 / Revised: 19 March 2012 / Accepted: 30 March 2012 / Published: 12 April 2012
(This article belongs to the Section Green Chemistry)
A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%–95% yield. View Full-Text
Keywords: silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition silica sulfuric acid; 5-substituted 1H-tetrazoles; [3+2] cycloaddition
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Du, Z.; Si, C.; Li, Y.; Wang, Y.; Lu, J. Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid. Int. J. Mol. Sci. 2012, 13, 4696-4703.

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