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Int. J. Mol. Sci. 2012, 13(12), 16708-16717;

Long Non-Coding RNAs and p53 Regulation

Gene Expression-Microarrays Laboratory, IRCCS-Bambino Gesù Children's Hospital, Rome 00165, Italy
Author to whom correspondence should be addressed.
Received: 5 November 2012 / Revised: 3 December 2012 / Accepted: 3 December 2012 / Published: 6 December 2012
(This article belongs to the Special Issue Non-Coding RNAs 2012)
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The advent of novel and high-throughput sequencing (next generation) technologies allowed for the sequencing of the genome at an unprecedented depth. The majority of transcribed RNAs have been classified as non-coding RNAs. Among them, long non-coding RNAs (lncRNAs) are emerging as important regulators in many biological processes. Here, we discuss the role of those lncRNAs which are under the control of p53 or that are able to regulate its activity, due to the central role of p53 pathway in many conditions. We also briefly discussed the emerging need of having novel strategies and computational tools to completely unravel the multifaceted roles of lncRNAs and to pave the way to the development of novel diagnostic and therapeutic applications based on these peculiar molecules. View Full-Text
Keywords: long non-coding RNAs; p53 pathway; LincRNA-p21; PANDA; H19; MEG3; LincRNA-EPS long non-coding RNAs; p53 pathway; LincRNA-p21; PANDA; H19; MEG3; LincRNA-EPS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Baldassarre, A.; Masotti, A. Long Non-Coding RNAs and p53 Regulation. Int. J. Mol. Sci. 2012, 13, 16708-16717.

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