MicroRNAs in Metal Stress: Specific Roles or Secondary Responses?
Abstract
:1. Introduction
2. Biogenesis and Working Mechanisms of miRNAs
2.1. MicroRNA Biogenesis and Incorporation in Protein Complexes
2.2. MicroRNAs Can Cause DNA Methylation
2.3. Argonaute Proteins and miRNA Function
2.4. MicroRNA Biogenesis Is Regulated by a miRNA Feedback Mechanism
3. The Role of miRNAs in Regulating Their Downstream Targets
3.1. MicroRNA Functioning in Development
3.2. MicroRNA Functioning in Stress Responses
4. The Role of miRNAs in Metal Stress
4.1. Role of miRNAs in Metal Complexation
4.2. Role in Oxidative Stress
4.3. Role in Signal Transduction
4.4. Other Metal Stress Regulated miRNAs
5. Stress-Specific Regulation of miRNAs Is Not Always Straightforwardly Connected to Beneficial Target Gene Regulation
6. Conclusions
Acknowledgments
- Conflict of InterestThe authors declare no conflict of interest.
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Gielen, H.; Remans, T.; Vangronsveld, J.; Cuypers, A. MicroRNAs in Metal Stress: Specific Roles or Secondary Responses? Int. J. Mol. Sci. 2012, 13, 15826-15847. https://doi.org/10.3390/ijms131215826
Gielen H, Remans T, Vangronsveld J, Cuypers A. MicroRNAs in Metal Stress: Specific Roles or Secondary Responses? International Journal of Molecular Sciences. 2012; 13(12):15826-15847. https://doi.org/10.3390/ijms131215826
Chicago/Turabian StyleGielen, Heidi, Tony Remans, Jaco Vangronsveld, and Ann Cuypers. 2012. "MicroRNAs in Metal Stress: Specific Roles or Secondary Responses?" International Journal of Molecular Sciences 13, no. 12: 15826-15847. https://doi.org/10.3390/ijms131215826