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Int. J. Mol. Sci. 2012, 13(12), 15784-15800;

Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms

Department of General Surgery, Huashan Hospital, Fudan University, 12 Middle Wulumiqi Road, Shanghai 200040, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 8 October 2012 / Revised: 5 November 2012 / Accepted: 12 November 2012 / Published: 26 November 2012
(This article belongs to the Special Issue Brain Metastasis)
Full-Text   |   PDF [189 KB, uploaded 19 June 2014]


Colorectal cancer is one of the most common digestive tract malignancies in the world. Owing to the newer and more effective systemic therapies, the life of colorectal cancer patients can be remarkably prolonged, and the incidence of brain metastases is increasing. However, little is known about the underlying mechanisms of brain metastasis from colorectal cancer. Here we review the tumor microenvironment and metastasis associated molecules in brain metastases from colorectal cancer. A further understanding of these mechanisms will help us to propose better strategies for colorectal cancer patients with brain metastasis and improve their life quality. View Full-Text
Keywords: colorectal cancer; brain metastasis; microenvironment colorectal cancer; brain metastasis; microenvironment
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zang, Y.-W.; Gu, X.-D.; Xiang, J.-B.; Chen, Z.-Y. Brain Metastases from Colorectal Cancer: Microenvironment and Molecular Mechanisms. Int. J. Mol. Sci. 2012, 13, 15784-15800.

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