Next Article in Journal
Variable Frequencies of Apolipoprotein E Genotypes and Its Effect on Serum Lipids in the Guangxi Zhuang and Han Children
Previous Article in Journal
New User-Friendly Approach to Obtain an Eisenberg Plot and Its Use as a Practical Tool in Protein Sequence Analysis
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2011, 12(9), 5592-5603;

Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises?

Department of Cardiology, Angiology and Pneumology, University of Heidelberg, D-69120 Heidelberg, Germany
Faculty of Medicine, University of Heidelberg, D-69120, Heidelberg, Germany
Author to whom correspondence should be addressed.
Received: 14 July 2011 / Revised: 17 August 2011 / Accepted: 19 August 2011 / Published: 31 August 2011
(This article belongs to the Section Biochemistry)
PDF [321 KB, uploaded 19 June 2014]


Epigallocatechin-3-gallate (EGCG), the main and most significant polyphenol in green tea, has shown numerous health promoting effects acting through different pathways, as antioxidant, anti-inflammatory and anti-atherogenic agent, showing gene expression activity, functioning through growth factor-mediated pathways, the mitogen-activated protein kinase-dependent pathway, the ubiquitin/proteasome degradation pathway, as well as eliciting an amyloid protein remodeling activity. However, epidemiological inferences are sometimes conflicting and in vitro and in vivo studies may seem discrepant. Current knowledge on how to enhance bioavailability could be the answer to some of these issues. Furthermore, dose levels, administration frequency and potential side effects remain to be examined. View Full-Text
Keywords: epigallocatechin-3-gallate; green tea; bioavailability epigallocatechin-3-gallate; green tea; bioavailability

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Mereles, D.; Hunstein, W. Epigallocatechin-3-gallate (EGCG) for Clinical Trials: More Pitfalls than Promises? Int. J. Mol. Sci. 2011, 12, 5592-5603.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top