Next Article in Journal
The Slowly Aggregating Salmon Calcitonin: A Useful Tool for the Study of the Amyloid Oligomers Structure and Activity
Next Article in Special Issue
Non Coding RNAs and Viruses in the Framework of the Phylogeny of the Genes, Epigenesis and Heredity
Previous Article in Journal
3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors
Previous Article in Special Issue
RNA Aptamer Evolution: Two Decades of SELEction
Open AccessArticle

Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method

Department of Physics, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan
Tohoku University School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Department of Cell Biology, the JFCR-Cancer Institute, 3-8-31, Ariake, Koto-ku, Tokyo 135-8550, Japan
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(12), 9265-9276;
Received: 24 October 2011 / Revised: 22 November 2011 / Accepted: 29 November 2011 / Published: 12 December 2011
(This article belongs to the Special Issue Non-Coding RNAs)
MicroRNA (miRNA) is a critical regulator of cell growth, differentiation, and development. To identify important miRNAs in a biological process, many bioinformatical tools have been developed. We have developed MiRaGE (MiRNA Ranking by Gene Expression) method to infer the regulation of gene expression by miRNAs from changes of gene expression profiles. The method does not require precedent array normalization. We applied the method to elucidate possibly important miRNAs during embryonic stem (ES) cell differentiation to neuronal cells and we infer that certain miRNAs, including miR-200 family, miR-429, miR-302 family, and miR-17-92 cluster members may be important to the maintenance of undifferentiated status in ES cells. View Full-Text
Keywords: miRNA; embryonic stem cell; MiRaGE metheod miRNA; embryonic stem cell; MiRaGE metheod
Show Figures

Graphical abstract

MDPI and ACS Style

Yoshizawa, M.; Taguchi, Y.-H.; Yasuda, J. Inference of Gene Regulation via miRNAs During ES Cell Differentiation Using MiRaGE Method. Int. J. Mol. Sci. 2011, 12, 9265-9276.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop