Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology
Abstract
:1. Introduction
2. Results and Discussion
2.1. Motor Unit Number Estimation (MUNE)
2.2. Macro-EMG
3. Experimental Section
3.1. Patients and Methods
3.2. Macro-EMG
3.3. Motor Unit Number Estimation (MUNE)
3.4. Statistical Analysis
4. Conclusions
Acknowledgements
References
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T0 | T1 | T2 | T3 | ||
---|---|---|---|---|---|
(mean ± 1 SD) | (mean ± 1 SD) | (mean ± 1 SD) | (mean ± 1 SD) | ||
BB Macro EMG | sALS | 4397.6 ± 255.9 | 6389.2 ± 586.3 | 6553 ± 498.7 | 8072.4 ± 1023.4 |
Area (μVms) | fALS | 4378.9 ± 319.6 | 7791.0 ± 953.4 | 10922.8 ± 1123.7 | 12499.3 ± 1874.4 |
BB Macro-EMG | sALS | 2.0 ± 0.3 | 2.1 ± 0.1 | 2.3 ± 0.3 | 2.5 ± 0.2 |
Fiber Density | fALS | 1.9 ± 0.3 | 2.5 ± 0.3 | 3.5 ± 0.6 | 3.9 ± 0.5 |
BB MUNE | sALS | 48.3 ± 9.3 | 34.1 ± 1.9 | 35.4 ± 1.4 | 30.8 ± 2.2 |
fALS | 80.2 ± 7.8 | 21.8 ± 2.2 | 16.8 ± 1.0 | 16.5 ± 2.0 | |
ADM MUNE | sALS | 35.6 ± 3.4 | 20.1 ± 1.8 | 22.8 ± 5.2 | 12.1 ± 5.8 |
fALS | 42.8 ± 6.6 | 18.4 ± 3.1 | 15.3 ± 2.1 | 9.0 ± 2.1 |
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Bocci, T.; Pecori, C.; Giorli, E.; Briscese, L.; Tognazzi, S.; Caleo, M.; Sartucci, F. Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology. Int. J. Mol. Sci. 2011, 12, 9203-9215. https://doi.org/10.3390/ijms12129203
Bocci T, Pecori C, Giorli E, Briscese L, Tognazzi S, Caleo M, Sartucci F. Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology. International Journal of Molecular Sciences. 2011; 12(12):9203-9215. https://doi.org/10.3390/ijms12129203
Chicago/Turabian StyleBocci, Tommaso, Chiara Pecori, Elisa Giorli, Lucia Briscese, Silvia Tognazzi, Matteo Caleo, and Ferdinando Sartucci. 2011. "Differential Motor Neuron Impairment and Axonal Regeneration in Sporadic and Familiar Amyotrophic Lateral Sclerosis with SOD-1 Mutations: Lessons from Neurophysiology" International Journal of Molecular Sciences 12, no. 12: 9203-9215. https://doi.org/10.3390/ijms12129203