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Article

New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036–330, Brazil
2
Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036–330, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2011, 12(12), 8993-9008; https://doi.org/10.3390/ijms12128993
Received: 14 October 2011 / Revised: 8 November 2011 / Accepted: 23 November 2011 / Published: 7 December 2011
(This article belongs to the Section Biochemistry)
The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 ± 3.00), 200 (42.00 ± 2.98) and 400 mg/kg (39.00 ± 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 ± 4.44) and 31.15% (400 mg/kg = 48.00 ± 4.37). The doses of 100 (43.37 ± 5.15), 200 (34.62 ± 4.16) and 400 mg/kg (28.37 ± 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 ± 0.39 and 11.14 ± 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved. View Full-Text
Keywords: Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity
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MDPI and ACS Style

Da Silva, J.B.; Temponi, V.d.S.; Fernandes, F.V.; Alves, G.d.A.D.; Matos, D.M.d.; Gasparetto, C.M.; Ribeiro, A.; De Pinho, J.d.J.R.G.; Alves, M.S.; De Sousa, O.V. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. Int. J. Mol. Sci. 2011, 12, 8993-9008. https://doi.org/10.3390/ijms12128993

AMA Style

Da Silva JB, Temponi VdS, Fernandes FV, Alves GdAD, Matos DMd, Gasparetto CM, Ribeiro A, De Pinho JdJRG, Alves MS, De Sousa OV. New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves. International Journal of Molecular Sciences. 2011; 12(12):8993-9008. https://doi.org/10.3390/ijms12128993

Chicago/Turabian Style

Da Silva, Jucélia Barbosa; Temponi, Vanessa dos Santos; Fernandes, Felipe Valente; Alves, Geórgia de Assis Dias; Matos, Dalyara Mendonça de; Gasparetto, Carolina Miranda; Ribeiro, Antônia; De Pinho, José de Jesus R. G.; Alves, Maria Silvana; De Sousa, Orlando Vieira. 2011. "New Approaches to Clarify Antinociceptive and Anti-Inflammatory Effects of the Ethanol Extract from Vernonia condensata Leaves" Int. J. Mol. Sci. 12, no. 12: 8993-9008. https://doi.org/10.3390/ijms12128993

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