Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat Cochlear Organotypic Cultures
Abstract
:1. Introduction
2. Results and Discussion
2.1. LBP Protection Against Cisplatin-Induced Hair Cell Death
2.2. LBP Reduced the Generation of ROS in Hair Cells
2.3. Effects of LBP on Mitochondrial ΔΨm
2.4. Discussion
3. Experimental Section
3.1. LBP Extract Processing
3.2. Animals and Dissection
3.3. Organ of Corti Culture
3.4. Cisplatin and LBP Treatment
3.5. Assessment of Hair Cells Death
3.6. ROS Levels in Organ of Corti Explant
3.7. Measurement of Mitochondrial Membrane Potential (ΔΨm)
3.8. Statistical Analysis
4. Conclusions
Acknowledgments
- Conflicts of InterestThe authors declare no conflicts of interest.
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Liu, Q.; Li, Y.; Hu, L.; Wang, D. Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat Cochlear Organotypic Cultures. Int. J. Mol. Sci. 2011, 12, 8982-8992. https://doi.org/10.3390/ijms12128982
Liu Q, Li Y, Hu L, Wang D. Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat Cochlear Organotypic Cultures. International Journal of Molecular Sciences. 2011; 12(12):8982-8992. https://doi.org/10.3390/ijms12128982
Chicago/Turabian StyleLiu, Quan, Yanqing Li, Li Hu, and Dehui Wang. 2011. "Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat Cochlear Organotypic Cultures" International Journal of Molecular Sciences 12, no. 12: 8982-8992. https://doi.org/10.3390/ijms12128982
APA StyleLiu, Q., Li, Y., Hu, L., & Wang, D. (2011). Lycium barbarum Polysaccharides Attenuate Cisplatin-Induced Hair Cell Loss in Rat Cochlear Organotypic Cultures. International Journal of Molecular Sciences, 12(12), 8982-8992. https://doi.org/10.3390/ijms12128982