Next Article in Journal
Chromatin Fiber Dynamics under Tension and Torsion
Next Article in Special Issue
An Overview of Recent Development in Composite Catalysts from Porous Materials for Various Reactions and Processes
Previous Article in Journal
Emission Characteristics of Organic Light-Emitting Diodes and Organic Thin-Films with Planar and Corrugated Structures
Previous Article in Special Issue
Investigations on the Mechanical Properties of Conducting Polymer Coating-Substrate Structures and Their Influencing Factors
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2010, 11(4), 1546-1556;

Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite

Chemistry Department, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran
Author to whom correspondence should be addressed.
Received: 12 March 2009 / Accepted: 12 April 2010 / Published: 12 April 2010
(This article belongs to the Special Issue Composite Materials)
Full-Text   |   PDF [308 KB, uploaded 19 June 2014]   |  


The preparation, characterization, and in vitro release of 5-aminosalicylic acid (5-ASA)from methacrylic acid (MAA)/perlite composites (APC) prepared via a sol–gel route are reported. The free-radical graft polymerization of methacrylic acid (MAA) onto perlite particles was studied experimentally. The grafting procedure consisted of surface activation with 3-(trimethoxysilyl) propyl methacrylate (TSPA), followed by free-radical graft polymerization of methacrylic acid (MAA) in ethyl acetate with 2,2΄-azobis-isobutyronitrile (AIBN) initiator. The composition of the composites hybrid materials was determined by FTIR spectroscopy. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The dried composites were immersed in a saturated solution of 5-ASA in water overnight and dried over a period of three days at room temperature and the in vitro release profiles were established separately in both (SGF, pH 1) and (SIF, pH 7.4). The 5-ASA concentration of the solution was measured using a UV-Vis spectrophotometer (205 nm) at different time intervals. The in vitro drug release test revealed that the release rate of 5-ASA in buffer solutions increased with the silica content in the composites; on the contrary, the increase of the content of 3-(trimethoxysilyl)propyl methacrylate (TSPA), a coupling agent, decreased the drug release rate. View Full-Text
Keywords: methacrylic acid; perlite; silylation; polymerization; polymer grafting methacrylic acid; perlite; silylation; polymerization; polymer grafting

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Mahkam, M.; Vakhshouri, L. Colon-Specific Drug Delivery Behavior of pH-Responsive PMAA/Perlite Composite. Int. J. Mol. Sci. 2010, 11, 1546-1556.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top