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Open AccessReview

Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs

1
Department of Surgery, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands
2
Department of Parasitology, Biomolecular Mass Spectrometry Unit, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands
3
Department of Medical Statistics, Leiden University Medical Center (LUMC), Albinusdreef 2, 2333 ZA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2010, 11(11), 4175-4193; https://doi.org/10.3390/ijms11114175
Received: 15 September 2010 / Revised: 16 October 2010 / Accepted: 18 October 2010 / Published: 26 October 2010
(This article belongs to the Special Issue Biomarkers)
Early diagnosis of cancer is of pivotal importance to reduce disease-related mortality. There is great need for non-invasive screening methods, yet current screening protocols have limited sensitivity and specificity. The use of serum biomarkers to discriminate cancer patients from healthy persons might be a tool to improve screening programs. Mass spectrometry based proteomics is widely applied as a technology for mapping and identifying peptides and proteins in body fluids. One commonly used approach in proteomics is peptide and protein profiling. Here, we present an overview of profiling methods that have the potential for implementation in a clinical setting and in national screening programs. View Full-Text
Keywords: mass spectrometry; biomarker; MALDI-TOF; SELDI-TOF; colorectal cancer; breast cancer; screening; proteomics; magnetic beads mass spectrometry; biomarker; MALDI-TOF; SELDI-TOF; colorectal cancer; breast cancer; screening; proteomics; magnetic beads
MDPI and ACS Style

Huijbers, A.; Velstra, B.; Dekker, T.J.A.; Mesker, W.E.; Burgt, Y.E.M.v.d.; Mertens, B.J.; Deelder, A.M.; Tollenaar, R.A.E.M. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs. Int. J. Mol. Sci. 2010, 11, 4175-4193. https://doi.org/10.3390/ijms11114175

AMA Style

Huijbers A, Velstra B, Dekker TJA, Mesker WE, Burgt YEMvd, Mertens BJ, Deelder AM, Tollenaar RAEM. Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs. International Journal of Molecular Sciences. 2010; 11(11):4175-4193. https://doi.org/10.3390/ijms11114175

Chicago/Turabian Style

Huijbers, Anouck; Velstra, Berit; Dekker, Tim J. A.; Mesker, Wilma E.; Burgt, Yuri E. M. van der; Mertens, Bart J.; Deelder, André M.; Tollenaar, Rob A. E. M. 2010. "Proteomic Serum Biomarkers and Their Potential Application in Cancer Screening Programs" Int. J. Mol. Sci. 11, no. 11: 4175-4193. https://doi.org/10.3390/ijms11114175

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