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The Diverse Applications of Cladistic Analysis of Molecular Evolution, with Special Reference to Nested Clade Analysis

Department of Biology, Washington University, St. Louis, MO 63130-4899, USA
Int. J. Mol. Sci. 2010, 11(1), 124-139; https://doi.org/10.3390/ijms11010124
Received: 25 November 2009 / Revised: 6 January 2010 / Accepted: 6 January 2010 / Published: 8 January 2010
(This article belongs to the Special Issue Cladistic Analysis and Molecular Evolution)
The genetic variation found in small regions of the genomes of many species can be arranged into haplotype trees that reflect the evolutionary genealogy of the DNA lineages found in that region and the accumulation of mutations on those lineages. This review demonstrates some of the many ways in which clades (branches) of haplotype trees have been applied in recent years, including the study of genotype/phenotype associations at candidate loci and in genome-wide association studies, the phylogeographic history of species, human evolution, the conservation of endangered species, and the identification of species. View Full-Text
Keywords: association studies; phylogeography; human evolution; conservation biology; species association studies; phylogeography; human evolution; conservation biology; species
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Templeton, A.R. The Diverse Applications of Cladistic Analysis of Molecular Evolution, with Special Reference to Nested Clade Analysis. Int. J. Mol. Sci. 2010, 11, 124-139.

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