Next Article in Journal / Special Issue
On the Free Energy That Drove Primordial Anabolism
Previous Article in Journal
In Vitro Cytochrome P450 Formation of a Mono-Hydroxylated Metabolite of Zearalenone Exhibiting Estrogenic Activities: Possible Occurrence of This Metabolite in Vivo
Previous Article in Special Issue
Non-Enzymatic Template-Directed Recombination of RNAs
Open AccessArticle

Coenzyme Autocatalytic Network on the Surface of Oil Microspheres as a Model for the Origin of Life

Genetics Laboratory, National Institute on Aging, NIA/NIH / 251 Bayview Boulevard, Baltimore, MD 21224, USA
Int. J. Mol. Sci. 2009, 10(4), 1838-1852; https://doi.org/10.3390/ijms10041838
Received: 17 February 2009 / Revised: 14 April 2009 / Accepted: 16 April 2009 / Published: 22 April 2009
(This article belongs to the Special Issue Origin of Life)
Coenzymes are often considered as remnants of primordial metabolism, but not as hereditary molecules. I suggest that coenzyme-like molecules (CLMs) performed hereditary functions before the emergence of nucleic acids. Autocatalytic CLMs modified (encoded) surface properties of hydrocarbon microspheres, to which they were anchored, and these changes enhanced autocatalysis and propagation of CLMs. Heredity started from a single kind of self-reproducing CLM, and then evolved into more complex coenzyme autocatalytic networks containing multiple kinds of CLMs. Polymerization of CLMs on the surface of microspheres and development of template-based synthesis is a potential evolutionary path towards the emergence of nucleic acids. View Full-Text
Keywords: Origin of life; coenzyme world; RNA world; hydrocarbon; coding relation Origin of life; coenzyme world; RNA world; hydrocarbon; coding relation
MDPI and ACS Style

Sharov, A.A. Coenzyme Autocatalytic Network on the Surface of Oil Microspheres as a Model for the Origin of Life. Int. J. Mol. Sci. 2009, 10, 1838-1852.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop