Next Article in Journal / Special Issue
The Synthesis of Dicationic Extended Bis-Benzimidazoles
Previous Article in Journal / Special Issue
Unexpected Syntheses of seco-Cyclopropyltetrahydroquinolines >From a Radical 5-Exo-Trig Cyclization Reaction: Analogs of CC-1065 and the Duocarmycins
Article Menu

Export Article

Open AccessArticle
Molecules 2004, 9(3), 134-157;

Lipid-Lowering Effects of Ethyl 2-Phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in Rodents

Department of Chemistry and Biochemistry, Rider University, 2083 Lawrenceville Rd., Lawrenceville, NJ 08648, USA
Department of Chemistry, University of Richmond, Richmond, VA 23173, USA
Department of Chemistry, UNC-Asheville, One University Heights, Asheville, NC 28801, USA
Author to whom correspondence should be addressed.
Published: 28 February 2004
(This article belongs to the Special Issue Biologically Relevant Heterocyclic Compounds)
Full-Text   |   PDF [246 KB, uploaded 18 June 2014]   |  


A series of substituted 2-phenacyl-3-phenyl-1H-pyrrole-4-carboxylates were prepared from substituted acetophenones in 6 steps. The final condensations between a chloroenal and an aminoketone were carried out under neutral conditions in parallel to yield the series listed below. Selected pyrrole derivatives proved to be potent hypolipidemic agents lowering serum triglyceride concentrations in CF-1 male mice after 14 days of I.P. administration. One agent orally lowered serum cholesterol in Sprague-Dawley male rats at 2mg/kg/day after 14 days. The agents demonstrated a lowering of mouse serum LDL- cholesterol levels and selected compounds showed an elevation of serum HDL-cholesterol levels. The cholesterol concentrations in the liver were raised while the cholesterol and triglyceride contents of the aorta were significantly lowered by the selected trisubstituted pyrrole. View Full-Text
Keywords: Pyrrole; hypolipidemia; cholesterol; triglyceride Pyrrole; hypolipidemia; cholesterol; triglyceride

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Holub, J.M.; O'Toole-Colin, K.; Getzel, A.; Argenti, A.; Evans, M.A.; Smith, D.C.; Dalglish, G.A.; Rifat, S.; Wilson, D.L.; Taylor, B.M.; Miott, U.; Glersaye, J.; Lam, K.S.; McCranor, B.J.; Berkowitz, J.D.; Miller, R.B.; Lukens, J.R.; Krumpe, K.; Gupton, J.T.; Burnham, B.S. Lipid-Lowering Effects of Ethyl 2-Phenacyl-3-aryl-1H-pyrrole- 4-carboxylates in Rodents. Molecules 2004, 9, 134-157.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top