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Molecules 2002, 7(6), 487-493;

An Efficient Preparation of 1,2-Diamino-1-phenylheptane

Organic Chemistry Laboratory, Central Leather Research Institute, Adyar, Chennai – 600 020. Tamil Nadu, India
Author to whom correspondence should be addressed.
Received: 12 December 2001 / Revised: 24 June 2002 / Accepted: 25 June 2002 / Published: 30 June 2002
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A convenient four-step method for the preparation of the lipophilic vicinal diamine 1,2-diamino-1-phenylheptane is described. Condensation involving octan-2-one, benzaldehyde and ammonia is reported. Regioselective Schmidt rearrangement of 2,6-diphenyl-3-pentyl-piperidin-4-one (1) to 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one (3) is presented. Hydrolysis of 2,7-diphenyl-3-pentyl hexahydrodiazapin-5-one to 1,2-diamino-1-phenylheptane (4) is also reported for the first time. View Full-Text
Keywords: Piperidinone; Schmidt rearrangement; Hexahydrodiazapinone; Vicinal diamine Piperidinone; Schmidt rearrangement; Hexahydrodiazapinone; Vicinal diamine

Figure 1

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Thennarasu, S.; Perumal, P.T. An Efficient Preparation of 1,2-Diamino-1-phenylheptane. Molecules 2002, 7, 487-493.

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