Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926
Abstract
:Introduction
Results and Discussion
Experimental
General Procedures and Materials
Computational Methods
2-Bromo-5-nitrobenzaldehyde
Isopropyl 4-(2-Bromo-5-nitrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (7)
Isopropyl 4-(2-Allyl-5-nitrophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (8)
Isopropyl 4-(2-Allyl-5-nitrophenyl)-3-[2-diazo-2-[(methyloxy)carbonyl]acetyl]-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (9)
1-tert.-Butyl 5-Isopropyl 4-(2-Allyl-5-nitrophenyl)-6-methyl-3-[2-diazo-2-[(methyloxy)carbonyl]-acetyl]-2-oxo-1,2,3,4-tetrahydro-1,5-pyrimidinedicarboxylate (10)
4-Isopropyl 15-Methyl 2-tert.-Butyl 3-Methyl-8-nitro-16-oxo-18-oxa-2,17-diazapentacyclo[13.2.1.01,13.05,17.06,11]octadeca-3,6,8,10-tetraene-2,4,15-tricarboxylate (12)
4-Isopropyl 15-Methyl 3-Methyl-8-nitro-16-oxo-18-oxa-2,17-diazapentacyclo[13.2.1.01,13.05,17.06,11]octadeca-3,6,8,10-tetraene-4,15-dicarboxylate (3)
Acknowledgements
References and Notes
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Jauk, B.; Pernat, T.; Kappe, C.O. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules 2000, 5, 227-239. https://doi.org/10.3390/50300227
Jauk B, Pernat T, Kappe CO. Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926. Molecules. 2000; 5(3):227-239. https://doi.org/10.3390/50300227
Chicago/Turabian StyleJauk, Birgit, Tetiana Pernat, and C. Oliver Kappe. 2000. "Design and Synthesis of a Conformationally Rigid Mimic of the Dihydropyrimidine Calcium Channel Modulator SQ 32,926" Molecules 5, no. 3: 227-239. https://doi.org/10.3390/50300227