Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy
Abstract
:1. Introduction
2. Study on Re in Cancer Therapy
2.1. Radioisotopes of Re for RT
2.2. Re Complexes in Cancer Therapy
2.2.1. Regulating the Expression of Related Proteins Causes Cancer Cells to Die
2.2.2. PDT Antiproliferation of Cancer Cells
2.2.3. Interaction with DNA to Inhibit Cancer Cells
2.2.4. Destroy the Function of Mitochondria and Kill Cancer Cells
2.2.5. Other Ways to Kill Cancer Cells
2.3. Re Nanomaterials in Cancer Therapy
3. Application of Re in Biological Imaging
3.1. Optical Imaging
3.2. CT Imaging
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Compound | Cell Line | Mechanism of Action | Ref. |
---|---|---|---|
Re-1a | HPAF-II, ASPC1, CFPAC | Inhibit Growth | [81] |
Re-2a | A2780, A2780CP70 | Inhibit Growth | [82] |
Re-3a | A2780, A2780CP70 | Cell Necrosis | [83] |
Re-4a | A549 | Cell Necrosis | [84] |
Re-4b | A549 | Cell Necrosis | [84] |
Re-5a | A431, DLD-1, A2780 | Cell Apoptosis | [85] |
Re-6a | HeLa | Cell Apoptosis and Ferroptosis | [86] |
Re-7a | Guerink (T-8) | Cell Apoptosis | [87] |
Re-8a | A549, HCT-15, HeLa, K562 | Cell Apoptosis | [88] |
Re-9a | A2780 | Cell Apoptosis | [89] |
Re-10a | A549 | Photodynamic Therapy | [90] |
Re-10b | A549 | Photodynamic Therapy | [90] |
Re-11a | HeLa | Photodynamic Therapy | [91] |
Re-12a | HeLa, H460M2, HBL-100 | Photodynamic Therapy | [92] |
Re-13a | HeLa | Photodynamic Therapy | [93] |
Re-13b | HeLa | Photodynamic Therapy | [93] |
Re-14a | A2780, A2780cis | Photodynamic Therapy | [94] |
Re-15a | HeLa, A2780, A2780CP70 | Photodynamic Therapy | [95] |
Re-16a | PC-3, MDA-MB-231, CCl-227 | Insert DNA | [96] |
Re-17a | PC-3 | Insert DNA | [97] |
Re-18a | / | Base Bind | [98] |
Re-19a | / | Base Bind | [99] |
Re-20a | / | DNA Groove Bind | [100] |
Re-21a | T98G, PC3, MCF-7 | DNA Groove Bind | [101] |
Re-22a | A2780/AD | DNA Groove Bind | [102] |
Re-23a | BeWo | DNA Groove Bind | [103] |
Re-24a | NCI-1229 | Cell Apoptosis | [104] |
Re-25a | HepG2, HeLa, MCF-7, A549 | Cell Apoptosis | [105] |
Re-26a | MCF-7 | Cell Apoptosis | [106] |
Re-27a | HeLa, A549, MCF-7 | Cell Apoptosis | [107] |
Re-27b | HeLa, A549, MCF-7 | Cell Apoptosis | [107] |
Re-28a | A549 | Cell Apoptosis | [108] |
Re-29a | HeLa | Cell Apoptosis | [109] |
Re-30a | NALM-6, BJAB, MelHO | Cell Apoptosis | [110] |
Re-31a | HeLa, A549, HepG2 | Cell Apoptosis | [111] |
Re-31b | HeLa, A549, HepG2 | Cell Paraptosis | [111] |
Re-32a | 4T1 | Sonodynamic–Gas Therapy | [112] |
Re-33a | MDA-MB-231 | Photodynamic and Immunotherapy | [113] |
Re-34a | HeLa | Cell Apoptosis | [114] |
Nanomaterials | Cell Line | Therapy Methods | Ref. |
---|---|---|---|
Re NCs | 4T1 | Photothermal Therapy | [131] |
PVP capped ReS2 | HeLa | Photothermal Therapy | [132] |
ReS2-PEG | 4T1 | Photothermal Radiotherapy | [133] |
PEG-ReS2 | 4T1 | Photothermal Therapy | [134] |
utReS2@RSV–FA | HepG2 | Chemo-Photothermal Therapy | [135] |
ReS2 NPs | 4T1 | Photothermal Therapy | [136] |
ReO3 NCs | HeLa | Photothermal Therapy | [137] |
Types of Materials | Therapy Methods | Advantage | Limitation |
---|---|---|---|
Re Radiopharmaceuticals | Radiotherapy | Simplicity of Operator | Kill Normal Cells |
Re Complexes | Regulating the Expression of Proteins | Extensive Mechanism | Unclear mechanism |
Photodynamic Therapy | Minimally Invasive | Limited Penetration | |
Interaction with DNA | Strong Targeting | Develop Resistance | |
Destroy the Function of Mitochondria | High Selectivity | Low Intake | |
Sonodynamic Therapy | Good Penetration | Oxygen Dependence | |
Immunotherapy | Wide Effect | Slow Action | |
Re Nanomaterials | Photothermal Therapy | High Efficiency | Limited Penetration |
Types of Materials | Imaging Techniques | Advantage | Limitation |
Re Nanomaterials | Infrared Thermal Imaging | Non-photobleach | Temperature-dependent |
Re Nanomaterials | Photoacoustic Imaging | High-resolution | Limited Penetration Depth |
Re Complexes | Fluorescence Imaging | Sensitive | Limited Penetration Depth |
Re Complexes | Phosphorescence Lifetime Imaging | Sensitive | Limited Penetration Depth |
Re Nanomaterials | Computed Tomography | High-resolution | Tissue Damage |
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Qi, Q.; Wang, Q.; Li, Y.; Silva, D.Z.; Ruiz, M.E.L.; Ouyang, R.; Liu, B.; Miao, Y. Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy. Molecules 2023, 28, 2733. https://doi.org/10.3390/molecules28062733
Qi Q, Wang Q, Li Y, Silva DZ, Ruiz MEL, Ouyang R, Liu B, Miao Y. Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy. Molecules. 2023; 28(6):2733. https://doi.org/10.3390/molecules28062733
Chicago/Turabian StyleQi, Qingwen, Qian Wang, Yuhao Li, Dionisio Zaldivar Silva, Maria Eliana Lanio Ruiz, Ruizhuo Ouyang, Baolin Liu, and Yuqing Miao. 2023. "Recent Development of Rhenium-Based Materials in the Application of Diagnosis and Tumor Therapy" Molecules 28, no. 6: 2733. https://doi.org/10.3390/molecules28062733