Antimicrobial Natural Products from Plant Pathogenic Fungi
Abstract
:1. Introduction
2. Results
3. Discussion
Fungus | ICMP | Compounds Isolated | Bioactivity | References |
---|---|---|---|---|
Alternaria radicina | 5619 | (E)-4,7-dihydroxyoct-2-enoic acid (1) | None | |
Radicinin (2) | Phytotoxic Antifungal Anti-proliferative Acetylcholinesterase inhibitor | [27,30,32,33,35] | ||
Terpestacin (3) | Anti-proliferative | [41] | ||
Tetrahydropyrenophorin (4) | Antibacterial Antifungal Algicidal | [36] | ||
Curvularin (5) | Phytotoxic | [9,23,26,38,42] | ||
Dehydrocurvularin (6) | Antifungal Phytotoxic Antimycobacterial | [9,23,26,42] | ||
Cercospora beticola | 15907 | Cercosporin (7) | Photo-activated plant toxin | [22,43] |
Dactylonectria macrodidyma | 16789 | Brefeldin A (8) (also known as Decumbin, Cyanein, Ascotoxin, Nectrolide, Synergisidin) | Anti-proliferative Antifungal | [19,38,44,45,46] |
Brefeldin C (9) | [20] | |||
Dactylonectria torresensis | 20542 | Brefeldin A (8) | Anti-proliferative | [19,38,44,45,46] |
Ilyonectria europaea | 16794 | Radicicol (10) (also known as Monorden) | HSP90 inhibitor Antifungal Antimalarial | [24,25,34,39,47] |
Ilyonectria liriodendra | 16795 | Radicicol (10) | HSP90 inhibitor Antifungal Antimalarial | [24,25,34,39,47] |
4. Materials and Methods
4.1. General Experimental Procedures
4.2. Fungal Material
4.2.1. ICMP 5619—Alternaria radicina
4.2.2. ICMP 15907—Cercospora beticola
4.2.3. ICMP 16789—Dactylonectria macrodidyma
4.2.4. ICMP 20542—Dactylonectria torresensis
4.2.5. ICMP 16794—Ilyonectria europaea
4.2.6. ICMP 16795—Ilyonectria liriodendri
4.3. Fermentation, Extraction and Isolation
4.3.1. ICMP 5619—Alternaria radicina
(E)-4,7-Dihydroxyoct-2-enoic acid (1)
Radicinin (2)
Terpestacin (3)
Tetrahydropyrenophorin (4)
Curvularin (5)
Dehydro-curvularin (6)
4.3.2. ICMP 15907—Cercospora beticola
Cercosporin (7)
4.3.3. ICMP 16789—Dactylonectria macrodidyma
Brefeldin A (8)
Brefeldin C (9)
4.3.4. ICMP 20542—Dactylonectria torresensis
4.3.5. ICMP 16794—Ilyonectria europaea
Radicicol (10)
4.3.6. ICMP 16795—Ilyonectria liriodendri
4.4. Antimicrobial Testing of Fungal Cultures
4.5. Antimicrobial Assays of Pure Compounds
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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MIC (µM) | HEK293 CC50 (µM) h | HC10 (µM) i | |||||||
---|---|---|---|---|---|---|---|---|---|
S. a a | E. c b | K. p c | P. a d | A. b e | C. a f | C. n g | |||
1 | >184 | >184 | >184 | >184 | >184 | >184 | >184 | n.t j | n.t j |
2 | >135 | >135 | >135 | >135 | >135 | >135 | >135 | n.t j | n.t j |
3 | >79 | >79 | >79 | >79 | >79 | >79 | >79 | n.t j | n.t j |
4 | >102 | >102 | >102 | >102 | >102 | >102 | >102 | n.t j | n.t j |
5 | >109 | >109 | >109 | >109 | >109 | >109 | >109 | n.t j | n.t j |
6 | >110 | >110 | >110 | >110 | >110 | >110 | >110 | 1.27 | >110 |
7 | ≤0.47 | >60 | >60 | >60 | >60 | >60 | >60 | 25.33 | >60 |
8 | >114 | >114 | >114 | >114 | >114 | 57 | >114 | 0.89 | >114 |
10 | >88 | >88 | >88 | >88 | >88 | 44 | >88 | >88 | >88 |
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Cadelis, M.M.; Li, S.A.; van de Pas, S.J.; Grey, A.; Mulholland, D.; Weir, B.S.; Copp, B.R.; Wiles, S. Antimicrobial Natural Products from Plant Pathogenic Fungi. Molecules 2023, 28, 1142. https://doi.org/10.3390/molecules28031142
Cadelis MM, Li SA, van de Pas SJ, Grey A, Mulholland D, Weir BS, Copp BR, Wiles S. Antimicrobial Natural Products from Plant Pathogenic Fungi. Molecules. 2023; 28(3):1142. https://doi.org/10.3390/molecules28031142
Chicago/Turabian StyleCadelis, Melissa M., Steven A. Li, Shara J. van de Pas, Alex Grey, Daniel Mulholland, Bevan S. Weir, Brent R. Copp, and Siouxsie Wiles. 2023. "Antimicrobial Natural Products from Plant Pathogenic Fungi" Molecules 28, no. 3: 1142. https://doi.org/10.3390/molecules28031142