Bringing Nitric Oxide to the Molybdenum World—A Personal Perspective
Abstract
:1. Context—I: The Molybdenum Side
2. Context—II: The Nitric Oxide Side
3. How it Began…
- (1)
- are mammalian XO/XD and AO able to generate NO? with what magnitude and kinetics? (aiming to confirm the enzymes’ ability to reduce nitrite to NO and study the kinetics and magnitude of NO generation);
- (2)
- how is it possible for XO (and similar enzymes) to catalyse an OAT-A reaction? (aiming to establish the reaction mechanism of nitrite-derived NO formation);
- (3)
- if no other organism is known to use a “true” molybdenum-dependent nitrite reductase to reduce nitrite to NO, why would a mammalian cell be able to do so? (aiming to assess the reaction physiological feasibility and significance).
4. My Journey on the Molybdenum-Dependent, “Non-Dedicated” Nitrite Reductases
4.1. Are Mammalian XO/XD and AO Able to Generate NO?
4.2. Kinetics and Magnitude of XO/XD- and AO-Generated NO
4.3. How Is It Possible for XO (and Similar Enzymes) to Catalyse an OAT-A Reaction?
4.4. If No Other Organism Is Known to Use a “True” Molybdenum-Dependent Nitrite Reductase to Reduce Nitrite to NO, Why Would a Mammalian Cell Be Able to Do So?
5. Concluding Remarks
Funding
Acknowledgments
Conflicts of Interest
Sample Availability
Abbreviations
References
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Maia, L.B. Bringing Nitric Oxide to the Molybdenum World—A Personal Perspective. Molecules 2023, 28, 5819. https://doi.org/10.3390/molecules28155819
Maia LB. Bringing Nitric Oxide to the Molybdenum World—A Personal Perspective. Molecules. 2023; 28(15):5819. https://doi.org/10.3390/molecules28155819
Chicago/Turabian StyleMaia, Luisa B. 2023. "Bringing Nitric Oxide to the Molybdenum World—A Personal Perspective" Molecules 28, no. 15: 5819. https://doi.org/10.3390/molecules28155819