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Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

1
Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh
2
Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt
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Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh
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Department of Pharmaceutical Science, North South University, Dhaka 1229, Bangladesh
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Department of Biochemistry and Molecular Biology, Faculty of Life Science, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh
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Department of Pharmacology and Toxicology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
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Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia
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Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
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Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania
*
Authors to whom correspondence should be addressed.
The authors contributed equally to this work.
Academic Editor: Akihito Yokosuka
Molecules 2022, 27(7), 2165; https://doi.org/10.3390/molecules27072165
Received: 10 February 2022 / Revised: 21 March 2022 / Accepted: 23 March 2022 / Published: 27 March 2022
(This article belongs to the Special Issue Natural Compounds: An Antidiabetic and Anticancer Agents)
Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates. View Full-Text
Keywords: natural compounds; antitumor; immune-suppressive; breast cancer; combination therapy natural compounds; antitumor; immune-suppressive; breast cancer; combination therapy
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MDPI and ACS Style

Islam, M.R.; Islam, F.; Nafady, M.H.; Akter, M.; Mitra, S.; Das, R.; Urmee, H.; Shohag, S.; Akter, A.; Chidambaram, K.; Alhumaydhi, F.A.; Emran, T.B.; Cavalu, S. Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint. Molecules 2022, 27, 2165. https://doi.org/10.3390/molecules27072165

AMA Style

Islam MR, Islam F, Nafady MH, Akter M, Mitra S, Das R, Urmee H, Shohag S, Akter A, Chidambaram K, Alhumaydhi FA, Emran TB, Cavalu S. Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint. Molecules. 2022; 27(7):2165. https://doi.org/10.3390/molecules27072165

Chicago/Turabian Style

Islam, Md. R., Fahadul Islam, Mohamed H. Nafady, Muniya Akter, Saikat Mitra, Rajib Das, Humaira Urmee, Sheikh Shohag, Aklima Akter, Kumarappan Chidambaram, Fahad A. Alhumaydhi, Talha B. Emran, and Simona Cavalu. 2022. "Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint" Molecules 27, no. 7: 2165. https://doi.org/10.3390/molecules27072165

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