Next Article in Journal
Oligoorganogermanes: Interplay between Aryl and Trimethylsilyl Substituents
Next Article in Special Issue
Optimizing Procedures of Ultrasound-Assisted Extraction of Waste Orange Peels by Response Surface Methodology
Previous Article in Journal
The Role of Hydrogen Bonds in Interactions between [PdCl4]2− Dianions in Crystal
Previous Article in Special Issue
Influence of Plant Extract Addition to Marinades on Polycyclic Aromatic Hydrocarbon Formation in Grilled Pork Meat
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 27
Issue 7
10.3390/molecules27072145
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

An Organic Solvent-Free Method for the Extraction of Ellagic Acid Compounds from Raspberry Wine Pomace with Assistance of Sodium Bicarbonate

by
Ning Jin
1,
Shouyu Zhang
1,
Shibo Sun
2,
Minghuo Wu
1,
Xiaojing Yang
1,
Jianqiang Xu
1,2,
Kun Ma
2,
Shui Guan
3 and
Weiping Xu
1,4,*
1
School of Ocean Science and Technology & Panjin Institute of Industrial Technology, Dalian University of Technology, Panjin 124221, China
2
School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China
3
State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116023, China
4
Key Laboratory of Industrial Ecology and Environmental Engineering, Dalian University of Technology, Dalian 116024, China
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(7), 2145; https://doi.org/10.3390/molecules27072145
Submission received: 28 February 2022 / Revised: 16 March 2022 / Accepted: 20 March 2022 / Published: 26 March 2022
(This article belongs to the Special Issue Sustainable Bioactive and Functional Molecules from Agri-Food Waste: A Tour to Applications)
Browse Figures
Versions Notes

Abstract

Industrial processing of raspberry juice and wine generates considerable byproducts of raspberry pomace. Ellagic acids/ellagitannins, being characterized by their antioxidant and antiproliferation properties, constitute the majority of polyphenolics in the pomace and are valuable for recovery. In the present study, we developed a novel procedure with sodium bicarbonate assisted extraction (SBAE) to recover ellagic acid from raspberry wine pomace. Key parameters in the procedure, i.e., sodium bicarbonate concentration, temperature, time and solid/liquid (S/L) ratio, were investigated by single factor analysis and optimized subsequently by Response Surface Methodology (RSM). Optimal parameters for the SBAE method here were found to be 1.2% (w/v) NaHCO3, 1:93 (w/v) S/L ratio, 22 min and 100 °C. Under these conditions, the ellagic acid yield was 6.30 ± 0.92 mg/g pomace with an antioxidant activity of 79.0 ± 0.96 μmol Trolox eq/g pomace (DPPH assay), which are 2.37 and 1.32 times the values obtained by extraction with methanol–acetone–water solvent, respectively. The considerable improvement in ellagic acid extraction efficiency could be highly attributed to the reactions of lipid saponification and ellagitannin hydrolysis resulted from sodium bicarbonates. The present study has established an organic solvent-free method for the extraction of ellagic acid from raspberry wine pomace, which is feasible and practical in nutraceutical applications.
Keywords: ellagic acid; extraction; raspberry; wine pomace; sodium bicarbonate; response surface methodology ellagic acid; extraction; raspberry; wine pomace; sodium bicarbonate; response surface methodology
Graphical Abstract

Share and Cite

MDPI and ACS Style

Jin, N.; Zhang, S.; Sun, S.; Wu, M.; Yang, X.; Xu, J.; Ma, K.; Guan, S.; Xu, W. An Organic Solvent-Free Method for the Extraction of Ellagic Acid Compounds from Raspberry Wine Pomace with Assistance of Sodium Bicarbonate. Molecules 2022, 27, 2145. https://doi.org/10.3390/molecules27072145

AMA Style

Jin N, Zhang S, Sun S, Wu M, Yang X, Xu J, Ma K, Guan S, Xu W. An Organic Solvent-Free Method for the Extraction of Ellagic Acid Compounds from Raspberry Wine Pomace with Assistance of Sodium Bicarbonate. Molecules. 2022; 27(7):2145. https://doi.org/10.3390/molecules27072145

Chicago/Turabian Style

Jin, Ning, Shouyu Zhang, Shibo Sun, Minghuo Wu, Xiaojing Yang, Jianqiang Xu, Kun Ma, Shui Guan, and Weiping Xu. 2022. "An Organic Solvent-Free Method for the Extraction of Ellagic Acid Compounds from Raspberry Wine Pomace with Assistance of Sodium Bicarbonate" Molecules 27, no. 7: 2145. https://doi.org/10.3390/molecules27072145

APA Style

Jin, N., Zhang, S., Sun, S., Wu, M., Yang, X., Xu, J., Ma, K., Guan, S., & Xu, W. (2022). An Organic Solvent-Free Method for the Extraction of Ellagic Acid Compounds from Raspberry Wine Pomace with Assistance of Sodium Bicarbonate. Molecules, 27(7), 2145. https://doi.org/10.3390/molecules27072145

Article Metrics

Back to TopTop