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Article

UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis

by 1,2, 2, 1 and 1,2,3,*
1
National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plant, Nanning 530000, China
2
National Chinmedomics Research Center, National TCM Key Laboratory of Serum Pharmacochemistry, Metabolomics Laboratory, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
3
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa 999078, Macau
*
Author to whom correspondence should be addressed.
Academic Editor: Dahong Li
Molecules 2022, 27(10), 3208; https://doi.org/10.3390/molecules27103208
Received: 9 April 2022 / Revised: 14 May 2022 / Accepted: 15 May 2022 / Published: 17 May 2022
(This article belongs to the Special Issue Natural Compounds: A Lead for Drug Discovery and Development)
Yunnan Baiyao is a famous Chinese patent medicine in Yunnan Province. However, its mechanism for promoting blood circulation and removing blood stasis is not fully explained. Our study used metabonomics technology to reveal the regulatory effect of Yunnan Baiyao on small molecular metabolites in promoting blood circulation and removing blood stasis, and exploring the related urine biomarkers. The coagulation function, blood rheology, and pathological results demonstrated that after Yunnan Baiyao treatment, the pathological indexes in rats with epinephrine hydrochloride-induced blood stasis syndrome improved and returned to normal levels. This is the basis for the effectiveness of Yunnan Baiyao. UPLC-G2Si-HDMS was used in combination with multivariate statistical analysis to conduct metabonomic analysis of urine samples. Finally, using mass spectrometry technology, 28 urine biomarkers were identified, clarifying the relevant metabolic pathways that play a vital role in the Yunnan Baiyao treatment. These were used as the target for Yunnan Baiyao to promote blood circulation and remove blood stasis. This study showed that metabolomics strategies provide opportunities and conditions for a deep and systematic understanding of the mechanism of action of prescriptions. View Full-Text
Keywords: Yunnan Baiyao; biomarker; metabolic pathway; metabolomics; UPLC-G2Si-HDMS Yunnan Baiyao; biomarker; metabolic pathway; metabolomics; UPLC-G2Si-HDMS
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MDPI and ACS Style

Zhang, Q.; Zhang, A.; Wu, F.; Wang, X. UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis. Molecules 2022, 27, 3208. https://doi.org/10.3390/molecules27103208

AMA Style

Zhang Q, Zhang A, Wu F, Wang X. UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis. Molecules. 2022; 27(10):3208. https://doi.org/10.3390/molecules27103208

Chicago/Turabian Style

Zhang, Qingyu, Aihua Zhang, Fangfang Wu, and Xijun Wang. 2022. "UPLC-G2Si-HDMS Untargeted Metabolomics for Identification of Yunnan Baiyao’s Metabolic Target in Promoting Blood Circulation and Removing Blood Stasis" Molecules 27, no. 10: 3208. https://doi.org/10.3390/molecules27103208

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