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Review

Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective

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Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh
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Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia
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Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India
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Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh
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Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo—Ourense Campus, E32004 Ourense, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Enrique Barrajon, Vicente Micol and María Herranz-López
Molecules 2021, 26(8), 2297; https://doi.org/10.3390/molecules26082297
Received: 14 March 2021 / Revised: 9 April 2021 / Accepted: 12 April 2021 / Published: 15 April 2021
(This article belongs to the Collection Featured Reviews in Natural Products Chemistry)
Plant-based indole alkaloids are very rich in pharmacological activities, and the indole nucleus is considered to contribute greatly to these activities. This review’s fundamental objective is to summarize the pharmacological potential of indole alkaloids that have been derived from plants and provide a detailed evaluation of their established pharmacological activities, which may contribute to identifying new lead compounds. The study was performed by searching various scientific databases, including Springer, Elsevier, ACS Publications, Taylor and Francis, Thieme, Wiley Online Library, ProQuest, MDPI, and online scientific books. A total of 100 indole compounds were identified and reviewed. The most active compounds possessed a variety of pharmacological activities, including anticancer, antibacterial, antiviral, antimalarial, antifungal, anti-inflammatory, antidepressant, analgesic, hypotensive, anticholinesterase, antiplatelet, antidiarrheal, spasmolytic, antileishmanial, lipid-lowering, antimycobacterial, and antidiabetic activities. Although some compounds have potent activity, some only have mild-to-moderate activity. The pharmacokinetic profiles of some of the identified compounds, such as brucine, mitragynine, 7-hydroxymitragynine, vindoline, and harmane, were also reviewed. Most of these compounds showed promising pharmacological activity. An in-depth pharmacological evaluation of these compounds should be performed to determine whether any of these indoles may serve as new leads. View Full-Text
Keywords: indole; alkaloids; pharmacological activity; pharmacokinetic profile; scientific databases indole; alkaloids; pharmacological activity; pharmacokinetic profile; scientific databases
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MDPI and ACS Style

Omar, F.; Tareq, A.M.; Alqahtani, A.M.; Dhama, K.; Sayeed, M.A.; Emran, T.B.; Simal-Gandara, J. Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules 2021, 26, 2297. https://doi.org/10.3390/molecules26082297

AMA Style

Omar F, Tareq AM, Alqahtani AM, Dhama K, Sayeed MA, Emran TB, Simal-Gandara J. Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective. Molecules. 2021; 26(8):2297. https://doi.org/10.3390/molecules26082297

Chicago/Turabian Style

Omar, Faisal, Abu M. Tareq, Ali M. Alqahtani, Kuldeep Dhama, Mohammed A. Sayeed, Talha B. Emran, and Jesus Simal-Gandara. 2021. "Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective" Molecules 26, no. 8: 2297. https://doi.org/10.3390/molecules26082297

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