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Nanoparticle-Based Rifampicin Delivery System Development

1
Centre of Polymer Systems, University Institute, TBU, tr. Tomase Bati 5678, 76001 Zlin, Czech Republic
2
iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 169-003 Lisbon, Portugal
3
Department of Chemistry, Faculty of Technology, TBU, Vavrečkova 275, 76001 Zlín, Czech Republic
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Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455/2, 12808 Prague 2, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Mariana Pinteala
Molecules 2021, 26(7), 2067; https://doi.org/10.3390/molecules26072067
Received: 3 March 2021 / Revised: 25 March 2021 / Accepted: 29 March 2021 / Published: 3 April 2021
The alkaline milieu of chronic wounds severely impairs the therapeutic effect of antibiotics, such as rifampicin; as such, the development of new drugs, or the smart delivery of existing drugs, is required. Herein, two innovative polyelectrolyte nanoparticles (PENs), composed of an amphiphilic chitosan core and a polycationic shell, were synthesized at alkaline pH, and in vitro performances were assessed by 1H NMR, elemental analysis, FT-IR, XRD, DSC, DLS, SEM, TEM, UV/Vis spectrophotometry, and HPLC. According to the results, the nanostructures exhibited different morphologies but similar physicochemical properties and release profiles. It was also hypothesized that the simultaneous use of the nanosystem and an antioxidant could be therapeutically beneficial. Therefore, the simultaneous effects of ascorbic acid and PENs were evaluated on the release profile and degradation of rifampicin, in which the results confirmed their synergistic protective effect at pH 8.5, as opposed to pH 7.4. Overall, this study highlighted the benefits of nanoparticulate development in the presence of antioxidants, at alkaline pH, as an efficient approach for decreasing rifampicin degradation. View Full-Text
Keywords: rifampicin; polyelectrolyte nanoparticles; ascorbic acid; alkaline pH rifampicin; polyelectrolyte nanoparticles; ascorbic acid; alkaline pH
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MDPI and ACS Style

Motiei, M.; Pleno de Gouveia, L.; Šopík, T.; Vícha, R.; Škoda, D.; Císař, J.; Khalili, R.; Domincová Bergerová, E.; Münster, L.; Fei, H.; Sedlařík, V.; Sáha, P. Nanoparticle-Based Rifampicin Delivery System Development. Molecules 2021, 26, 2067. https://doi.org/10.3390/molecules26072067

AMA Style

Motiei M, Pleno de Gouveia L, Šopík T, Vícha R, Škoda D, Císař J, Khalili R, Domincová Bergerová E, Münster L, Fei H, Sedlařík V, Sáha P. Nanoparticle-Based Rifampicin Delivery System Development. Molecules. 2021; 26(7):2067. https://doi.org/10.3390/molecules26072067

Chicago/Turabian Style

Motiei, Marjan; Pleno de Gouveia, Luis; Šopík, Tomáš; Vícha, Robert; Škoda, David; Císař, Jaroslav; Khalili, Reza; Domincová Bergerová, Eva; Münster, Lukáš; Fei, Haojie; Sedlařík, Vladimír; Sáha, Petr. 2021. "Nanoparticle-Based Rifampicin Delivery System Development" Molecules 26, no. 7: 2067. https://doi.org/10.3390/molecules26072067

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