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Review

Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review

by
Xianqin Wei
1,*,
Weibin Ruan
1 and
Klaas Vrieling
2
1
Institute of Entomology, College of Life Sciences, Nankai University, Tianjin 300071, China
2
Plant Science and Natural Products, Institute of Biology, Leiden University, Sylviusweg 72, P.O. Box 9505, 2300 RA Leiden, The Netherlands
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(7), 1970; https://doi.org/10.3390/molecules26071970
Submission received: 28 February 2021 / Revised: 21 March 2021 / Accepted: 27 March 2021 / Published: 31 March 2021
(This article belongs to the Special Issue Alkaloids in Future Drug Discovery)
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Abstract

Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals. In recent decades, the application of PAs for beneficial biological activities to cure disease has drawn greater attention. Here, we review the current knowledge regarding the pharmacological properties of PAs and discuss PAs as promising prototypes for the development of new drugs.
Keywords: plant secondary metabolites; pharmacy; alkaloids; herb medicine; defense; regulations plant secondary metabolites; pharmacy; alkaloids; herb medicine; defense; regulations

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MDPI and ACS Style

Wei, X.; Ruan, W.; Vrieling, K. Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review. Molecules 2021, 26, 1970. https://doi.org/10.3390/molecules26071970

AMA Style

Wei X, Ruan W, Vrieling K. Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review. Molecules. 2021; 26(7):1970. https://doi.org/10.3390/molecules26071970

Chicago/Turabian Style

Wei, Xianqin, Weibin Ruan, and Klaas Vrieling. 2021. "Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review" Molecules 26, no. 7: 1970. https://doi.org/10.3390/molecules26071970

APA Style

Wei, X., Ruan, W., & Vrieling, K. (2021). Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review. Molecules, 26(7), 1970. https://doi.org/10.3390/molecules26071970

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