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Article

Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability

1
Traditional Chinese Medicine College, Shenyang Pharmaceutical University, Shenyang 110016, China
2
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Josef Jampilek
Molecules 2021, 26(6), 1795; https://doi.org/10.3390/molecules26061795
Received: 24 February 2021 / Revised: 15 March 2021 / Accepted: 18 March 2021 / Published: 23 March 2021
(This article belongs to the Special Issue State-of-the-Art Analytical Technologies for Natural Products)
As the main component of Platycladus orientalis, cedrol has known germinal activity. A range of cedrol formulations have been developed to prevent hair-loss, but compliance remains key issues. In this study, we prepared cedrol nanoemulsion (CE-NE) and determined the particle size and PDI (polydispersion coefficient), investigated the hair growth activity and studied the bioavailability in vitro and in vivo. Results showed that the average particle size of CE-NE is 14.26 ± 0.16 nm, and the PDI value is 0.086 ± 0.019. In vitro drug release investigation and drug release kinetics analysis showed release profile of CE from nanoparticles demonstrates the preferred partition of CE in buffer pH 4.0, the release profile of CE-NE showed a first-order kinetics reaching around 36.7% after 6 h at 37 °C. We artificially depilated the back hair of C57BL/6 mice and compared the efficacy of a designed cedrol nanoemulsion to an existing ointment group. The hair follicles were imaged and quantified using a digital photomicrograph. The results showed that compared with the ointment, CE-NE had positive effects on hair growth, improved drug solubility. Compared with the ointment and 2% minoxidil groups, 50 mg/mL CE-NE led to more robust hair growth. Pharmacokinetics analysis showed that the AUC0–t of CE-NE was 4-fold higher than that of the ointment group, confirming that the bioavailability of the nanoemulsion was greater than that of the ointment. CE-NE also significantly reduced the hair growth time of model mice and significantly increased the growth rate of hair follicles. In conclusion, these data suggest that the nanoemulsion significantly improved the pharmacokinetic properties and hair growth effects cedrol, enhancing its efficacy in vitro and in vivo. View Full-Text
Keywords: cedrol; nanoemulsion; hair growth; pharmacokinetics; pharmacodynamics cedrol; nanoemulsion; hair growth; pharmacokinetics; pharmacodynamics
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MDPI and ACS Style

Deng, Y.; Huang, F.; Wang, J.; Zhang, Y.; Zhang, Y.; Su, G.; Zhao, Y. Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability. Molecules 2021, 26, 1795. https://doi.org/10.3390/molecules26061795

AMA Style

Deng Y, Huang F, Wang J, Zhang Y, Zhang Y, Su G, Zhao Y. Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability. Molecules. 2021; 26(6):1795. https://doi.org/10.3390/molecules26061795

Chicago/Turabian Style

Deng, Yaling, Feixue Huang, Jiewen Wang, Yumeng Zhang, Yan Zhang, Guangyue Su, and Yuqing Zhao. 2021. "Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability" Molecules 26, no. 6: 1795. https://doi.org/10.3390/molecules26061795

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