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Article

A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity

School of Forensic Medicine, China Medical University, Shenyang 110122, China
*
Author to whom correspondence should be addressed.
The authors contributed equally to this work.
Academic Editors: Mário Barroso, Eugenia Gallardo and Luís Passarinha
Molecules 2021, 26(6), 1748; https://doi.org/10.3390/molecules26061748
Received: 9 February 2021 / Revised: 16 March 2021 / Accepted: 17 March 2021 / Published: 20 March 2021
Nutmeg is a traditional spice and medicinal plant with a variety of pharmacological activities. However, nutmeg abuse due to its hallucinogenic characteristics and poisoning cases are frequently reported. Our previous metabolomics study proved the hepatotoxicity of nutmeg and demonstrated that high-dose nutmeg can affect the synthesis and secretion of bile acids and cause oxidative stress. In order to further investigate the hepatotoxicity of nutmeg, normal saline, 1 g/kg, 4 g/kg nutmeg were administrated to male Kunming mice by intragastrical gavage for 7 days. Histopathological investigation of liver tissue, proteomics and biochemical analysis were employed to explore the mechanism of liver damage caused by nutmeg. The results showed that a high-dose (4 g/kg) of nutmeg can cause significant increased level of CYP450s and depletion of antioxidants, resulting in obvious oxidative stress damage and lipid metabolism disorders; but this change was not observed in low-dose group (1 g/kg). In addition, the increased level of malondialdehyde and decreased level of glutathione peroxidase were found after nutmeg exposure. Therefore, the present study reasonably speculates that nutmeg exposure may lead to liver injury through oxidative stress and the degree of this damage is related to the exposure dose. View Full-Text
Keywords: nutmeg; hepatotoxicity; proteomics; oxidative stress; CYP450s; lipid peroxidation nutmeg; hepatotoxicity; proteomics; oxidative stress; CYP450s; lipid peroxidation
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MDPI and ACS Style

Xia, W.; Cao, Z.; Zhang, X.; Gao, L. A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity. Molecules 2021, 26, 1748. https://doi.org/10.3390/molecules26061748

AMA Style

Xia W, Cao Z, Zhang X, Gao L. A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity. Molecules. 2021; 26(6):1748. https://doi.org/10.3390/molecules26061748

Chicago/Turabian Style

Xia, Wei, Zhipeng Cao, Xiaoyu Zhang, and Lina Gao. 2021. "A Proteomics Study on the Mechanism of Nutmeg-Induced Hepatotoxicity" Molecules 26, no. 6: 1748. https://doi.org/10.3390/molecules26061748

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