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Article

S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells

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Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan
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R&D, Business Strategy, Healthcare SBU, Daicel Corporation, 2-18-1, Konan, Minato-ku, Tokyo 108-8230, Japan
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Arai Plant, Daicel Corporation, 1-1, Shinko-cho, Myoko 944-8550, Japan
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Innovation and Business Development Headquarters, Daicel Corporation, 1-8-23, Konan, Minato-ku, Tokyo 108-0075, Japan
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International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Simona Collina
Molecules 2021, 26(6), 1697; https://doi.org/10.3390/molecules26061697
Received: 23 February 2021 / Revised: 13 March 2021 / Accepted: 16 March 2021 / Published: 18 March 2021
Hypogonadism, associated with low levels of testosterone synthesis, has been implicated in several diseases. Recently, the quest for natural alternatives to prevent and treat hypogonadism has gained increasing research interest. To this end, the present study explored the effect of S-allyl cysteine (SAC), a characteristic organosulfur compound in aged-garlic extract, on testosterone production. SAC was administered at 50 mg/kg body weight intraperitoneally into 7-week-old BALB/c male mice in a single-dose experiment. Plasma levels of testosterone and luteinizing hormone (LH) and testis levels of proteins involved in steroidogenesis were measured by enzymatic immunoassay and Western blot, respectively. In addition, mouse testis-derived I-10 cells were also used to investigate the effect of SAC on steroidogenesis. In the animal experiment, SAC significantly elevated testosterone levels in both the plasma and the testis without changing the LH level in plasma and increased phosphorylated protein kinase A (p-PKA) levels. Similar results were also observed in I-10 cells. The findings demonstrating the increasing effect of SAC on p-PKA and mRNA levels of Cyp11a suggest that SAC increases the testosterone level by activating the PKA pathway and could be a potential target for hypogonadism therapeutics. View Full-Text
Keywords: S-allyl cysteine; testosterone; protein kinase A S-allyl cysteine; testosterone; protein kinase A
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MDPI and ACS Style

Rana, M.M.; Shiozawa, K.; Mukai, K.; Takayanagi, K.; Eguchi, K.; Sultana, H.; Ohsaki, Y.; Komai, M.; Shirakawa, H. S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells. Molecules 2021, 26, 1697. https://doi.org/10.3390/molecules26061697

AMA Style

Rana MM, Shiozawa K, Mukai K, Takayanagi K, Eguchi K, Sultana H, Ohsaki Y, Komai M, Shirakawa H. S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells. Molecules. 2021; 26(6):1697. https://doi.org/10.3390/molecules26061697

Chicago/Turabian Style

Rana, Md M.; Shiozawa, Kota; Mukai, Katsuyuki; Takayanagi, Katsuhiko; Eguchi, Koichi; Sultana, Halima; Ohsaki, Yusuke; Komai, Michio; Shirakawa, Hitoshi. 2021. "S-allyl Cysteine Enhances Testosterone Production in Mice and Mouse Testis-Derived I-10 Cells" Molecules 26, no. 6: 1697. https://doi.org/10.3390/molecules26061697

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