NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases
Abstract
:1. Introduction
1.1. PRRs That Regulate Inflammasome Formation
1.2. The NLRP3 Inflammasome
2. Mechanisms of NLRP3 Activation in the Heart
3. Role of the NLRP3 Inflammasome in the Development of Cardiovascular Diseases
4. NLRP3 Inflammasome as a Target for Pharmacological Inhibition
4.1. NLRP3 Inhibitors
4.1.1. Glyburide, 16673-34-0, and JC-124
4.1.2. MCC950
4.1.3. Bay 11-7082
4.1.4. OLT1177
4.1.5. INF4E
4.1.6. Tranilast
4.1.7. CY-09
4.1.8. Colchicine
4.1.9. Hydrogen Sulfide
5. Inhibition of Caspase-1, IL-1, and IL-18
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mezzaroma, E.; Abbate, A.; Toldo, S. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules 2021, 26, 976. https://doi.org/10.3390/molecules26040976
Mezzaroma E, Abbate A, Toldo S. NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules. 2021; 26(4):976. https://doi.org/10.3390/molecules26040976
Chicago/Turabian StyleMezzaroma, Eleonora, Antonio Abbate, and Stefano Toldo. 2021. "NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases" Molecules 26, no. 4: 976. https://doi.org/10.3390/molecules26040976