Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. SPR Assay
3. Materials and Methods
3.1. Chemistry
3.1.1. Preparation of SGP
3.1.2. Preparation of SCT-Asn
3.1.3. Preparation of SCT-Asn-Alkyne
3.1.4. General Procedure for Preparing Pentacyclic Triterpenes with the Azide Group
UA-N3
OA-N3
BA-N3
GA-N3
3.1.5. General Procedure for Preparing SCT-Asn-Pentacyclic Triterpene Conjugates
SCT-Asn-UA
SCT-Asn-OA
SCT-Asn-BA
SCT-Asn-GA
3.2. SPR Assay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
Compounds | H1N1(A/WSN/1933) | H5N1(A/Hong Kong/483/97) |
---|---|---|
SGP | ND | ND |
SCT-Asn | 29.04 | 75.46 |
UA | 136.70 | ND |
BA | ND | ND |
OA | 31.14 | 47.78 |
GA | 584.00 | >1000 |
SCT-Asn-UA | 289.40 | 852.70 |
SCT-Asn-BA | 6.89 | 251.60 |
SCT-Asn-OA | 11.24 | 9.10 |
SCT-Asn-GA | 16.35 | 13.24 |
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Luo, M.; Wu, X.; Li, Y.; Guo, F. Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin. Molecules 2021, 26, 895. https://doi.org/10.3390/molecules26040895
Luo M, Wu X, Li Y, Guo F. Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin. Molecules. 2021; 26(4):895. https://doi.org/10.3390/molecules26040895
Chicago/Turabian StyleLuo, Mei, Ximin Wu, Yiming Li, and Fujiang Guo. 2021. "Synthesis of Four Pentacyclic Triterpene–Sialylglycopeptide Conjugates and Their Affinity Assays with Hemagglutinin" Molecules 26, no. 4: 895. https://doi.org/10.3390/molecules26040895