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Article

Phytochemical Investigation and Biological Activities of Lantana rhodesiensis

1
Laboratory of Constitution and Reaction of Matter, UFR-SSMT, University Félix Houphouët-Boigny, 01 BP 582 Abidjan 01, Ivory Coast
2
Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés 2, 5030 Gembloux, Belgium
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Laboratory of Pharmacognosy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Avenue Hippocrate 15, 4000 Liège, Belgium
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Laboratory of Phytochemistry, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033 Yaoundé, Cameroon
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MolSys Research Unit, Faculty of Sciences, University of Liège, 4000 Liège, Belgium
*
Author to whom correspondence should be addressed.
Academic Editors: Simona Fabroni, Krystian Marszałek and Aldo Todaro
Molecules 2021, 26(4), 846; https://doi.org/10.3390/molecules26040846
Received: 8 January 2021 / Revised: 29 January 2021 / Accepted: 3 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Discovery of Bioactive Ingredients from Natural Products)
Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the β-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3′,5′-tetrahydroxy-7,4′-dimethoxyflavone) (1), 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (3), and 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (4). Their structures were elucidated by 1H, 13CNMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species. View Full-Text
Keywords: Lantana rhodesiensis; polyphenol content; flavonoid content; antioxidant activity; anti-malarial activity; flavones Lantana rhodesiensis; polyphenol content; flavonoid content; antioxidant activity; anti-malarial activity; flavones
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MDPI and ACS Style

Nea, F.; Bitchi, M.B.; Genva, M.; Ledoux, A.; Tchinda, A.T.; Damblon, C.; Frederich, M.; Tonzibo, Z.F.; Fauconnier, M.-L. Phytochemical Investigation and Biological Activities of Lantana rhodesiensis. Molecules 2021, 26, 846. https://doi.org/10.3390/molecules26040846

AMA Style

Nea F, Bitchi MB, Genva M, Ledoux A, Tchinda AT, Damblon C, Frederich M, Tonzibo ZF, Fauconnier M-L. Phytochemical Investigation and Biological Activities of Lantana rhodesiensis. Molecules. 2021; 26(4):846. https://doi.org/10.3390/molecules26040846

Chicago/Turabian Style

Nea, Fatimata, Michel B. Bitchi, Manon Genva, Allison Ledoux, Alembert T. Tchinda, Christian Damblon, Michel Frederich, Zanahi F. Tonzibo, and Marie-Laure Fauconnier. 2021. "Phytochemical Investigation and Biological Activities of Lantana rhodesiensis" Molecules 26, no. 4: 846. https://doi.org/10.3390/molecules26040846

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