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Article

New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities

by
Hee Jae Shin
1,2,*,
Cao Van Anh
1,2,
Duk-Yeon Cho
3,
Dong-Kug Choi
3,
Jong Soon Kang
4,
Phan Thi Hoai Trinh
5,
Byeoung-Kyu Choi
1 and
Hwa-Sun Lee
1
1
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Korea
2
Department of Marine Biotechnology, University of Science and Technology (UST), 217 Gajungro, Yuseong-gu, Daejeon 34113, Korea
3
Department of Applied Life Science, Graduate school, BK21 Program, Konkuk University, Chungju 27478, Korea
4
Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Korea
5
Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong, Nha Trang 650000, Vietnam
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(4), 836; https://doi.org/10.3390/molecules26040836
Submission received: 24 December 2020 / Revised: 29 January 2021 / Accepted: 2 February 2021 / Published: 5 February 2021
(This article belongs to the Special Issue Marine Natural Product Chemistry: A Themed Issue in Honor of Professor Peter Proksch on His Research Career)
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Abstract

Three new polyene compounds, talacyanols A–C (1–3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1–5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher’s methods, as well as comparison with previously reported literature data. All the compounds (1–5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.
Keywords: Talaromyces cyanescens; marine-derived fungus; polyenes; cytotoxicity; anti-neuroinflammatory Talaromyces cyanescens; marine-derived fungus; polyenes; cytotoxicity; anti-neuroinflammatory

Share and Cite

MDPI and ACS Style

Shin, H.J.; Anh, C.V.; Cho, D.-Y.; Choi, D.-K.; Kang, J.S.; Trinh, P.T.H.; Choi, B.-K.; Lee, H.-S. New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities. Molecules 2021, 26, 836. https://doi.org/10.3390/molecules26040836

AMA Style

Shin HJ, Anh CV, Cho D-Y, Choi D-K, Kang JS, Trinh PTH, Choi B-K, Lee H-S. New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities. Molecules. 2021; 26(4):836. https://doi.org/10.3390/molecules26040836

Chicago/Turabian Style

Shin, Hee Jae, Cao Van Anh, Duk-Yeon Cho, Dong-Kug Choi, Jong Soon Kang, Phan Thi Hoai Trinh, Byeoung-Kyu Choi, and Hwa-Sun Lee. 2021. "New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities" Molecules 26, no. 4: 836. https://doi.org/10.3390/molecules26040836

APA Style

Shin, H. J., Anh, C. V., Cho, D.-Y., Choi, D.-K., Kang, J. S., Trinh, P. T. H., Choi, B.-K., & Lee, H.-S. (2021). New Polyenes from the Marine-Derived Fungus Talaromyces cyanescens with Anti-Neuroinflammatory and Cytotoxic Activities. Molecules, 26(4), 836. https://doi.org/10.3390/molecules26040836

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